Pulse lineResearch With Heart Logo

Functional status declines among cancer survivors: trajectory and contributing factors.

TitleFunctional status declines among cancer survivors: trajectory and contributing factors.
Publication TypeJournal Article
Year of Publication2014
AuthorsPetrick JL, Reeve BB, Kucharska-Newton AMaria, Foraker RE, Platz EA, Stearns SC, Han X, B Windham G
Secondary AuthorsIrwin DE
JournalJ Geriatr Oncol
Volume5
Issue4
Pagination359-67
Date Published2014 Oct 01
ISSN1879-4076
KeywordsActivities of Daily Living, Breast Neoplasms, Cohort Studies, Colorectal Neoplasms, Female, Follow-Up Studies, Health Status, Humans, Lung Neoplasms, Male, Middle Aged, Prospective Studies, Prostatic Neoplasms, Risk Factors, Survivors, United States
Abstract

OBJECTIVE: This study aimed to quantify functional status (FS) trajectories pre- and post-diagnosis of cancer, FS trajectories among cancer-free individuals, and factors affecting FS.

MATERIALS AND METHODS: Self-reported FS, scored from 0 (worst) to 100 (best), of Atherosclerosis Risk in Communities (ARIC) Study cohort participants diagnosed with incident cancer (lung (N=303), breast (N=374), prostate (N=529), colorectal (N=228)), and cancer-free participants (N=11,155) over 15 years was examined. FS was evaluated in two ways: 1) until death or follow-up year 15 (Model 1) and 2) same as survivorship model except that a FS value of zero was used for assessments after death to follow-up year 15 (Model 2). Mean FS at discrete time points were used to generate FS trajectories. Differences in repeated measures of FS were assessed using linear growth models.

RESULTS: Within one year after diagnosis, FS scores declined compared to the cancer-free group, except for prostate cancer. FS continued to decline beyond one year after lung or colorectal cancer diagnosis. FS was lower in all cancer groups, except prostate, compared to the cancer-free group (Model 1: lung -4.76, breast -2.28, colorectal -2.55; Model 2: lung -2.36, breast -2.46, colorectal -2.31). Predictors of decreased FS score independent of cancer diagnosis included low education, comorbidities, obesity, smoking, lack of health insurance, and age.

CONCLUSION: FS in all incident cancer groups declined during the first year post-diagnosis, which could be due to intensive treatments. Targeting factors related to FS declines could improve health outcomes for patients with cancer.

DOI10.1016/j.jgo.2014.06.002
Alternate JournalJ Geriatr Oncol
PubMed ID24981125
PubMed Central IDPMC4254190
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
U01 CA164975 / CA / NCI NIH HHS / United States
U01 CA164975-01 / CA / NCI NIH HHS / United States