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Plasma lactate and incident hypertension in the atherosclerosis risk in communities study.

TitlePlasma lactate and incident hypertension in the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2015
AuthorsJuraschek SP, Bower JK, Selvin E, Shantha GPalamaner, Hoogeveen RC, Ballantyne CM
Secondary AuthorsYoung HJ
JournalAm J Hypertens
Volume28
Issue2
Pagination216-24
Date Published2015 Feb
ISSN1941-7225
KeywordsAged, Cohort Studies, Female, Humans, Hypertension, Incidence, Lactic Acid, Longitudinal Studies, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Sex Factors
Abstract

BACKGROUND: Recent evidence suggests that insufficient oxidative capacity or mitochondrial dysfunction may play a causal role in the development of high blood pressure. However, this hypothesis has not been tested in the general population. We hypothesized that lactate, a measure of oxidative capacity, would be positively associated with incident hypertension even after accounting for traditional hypertension risk factors.

METHODS: Plasma lactate was measured in 5,554 participants from the Atherosclerosis Risk in Communities (ARIC) Study with no subclinical or diagnosed hypertension at baseline (1996-1998). Incident hypertension was defined by self-report or hypertension medication use. Analyses were performed with Cox proportional hazards models.

RESULTS: The mean age was 61.9 years, and the mean lactate was 0.8 mmol/L. During a median follow-up period of 11.9 years (range = 26.9 days to 13.4 years), there were 3,849 new cases of hypertension. The fourth quartile of lactate (compared with the first quartile) was associated with an elevated risk of hypertension (hazard ratio (HR) = 1.18; 95% confidence interval (CI) = 1.07-1.31) even after adjustment for traditional risk factors, including baseline systolic and diastolic blood pressure. This association was stronger when the population was restricted to participants with normal blood pressure (

CONCLUSIONS: Plasma lactate is associated with incident hypertension in women, especially with a normal blood pressure (

DOI10.1093/ajh/hpu117
Alternate JournalAm J Hypertens
PubMed ID24994607
PubMed Central IDPMC4357800
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100012C) / / PHS HHS / United States
R01DK085458 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
5P60DK079637-04 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
R01 DK085458 / DK / NIDDK NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
P60 DK079637 / DK / NIDDK NIH HHS / United States
T32HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States