Title | Serum fibroblast growth factor-23 is associated with incident kidney disease. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Rebholz CM, Grams ME, Coresh JJ, Selvin E, Inker LA, Levey AS, Kimmel PL, Vasan RS, Eckfeldt JH, Feldman HI, Hsu C-Y |
Secondary Authors | Lutsey PL |
Corporate Authors | Chronic Kidney Disease Biomarkers Consortium |
Journal | J Am Soc Nephrol |
Volume | 26 |
Issue | 1 |
Pagination | 192-200 |
Date Published | 2015 Jan |
ISSN | 1533-3450 |
Keywords | Adult, Age Factors, Aged, Atherosclerosis, Cohort Studies, Disease Progression, Female, Fibroblast Growth Factors, Gene Expression Regulation, Glomerular Filtration Rate, Humans, Kidney Diseases, Male, Middle Aged, Risk Factors, Sex Factors, Vitamin D |
Abstract | Fibroblast growth factor-23 is a bone-derived hormone that increases urinary phosphate excretion and inhibits hydroxylation of 25-hydroxyvitamin D. Recent studies suggest that fibroblast growth factor-23 may be an early biomarker of CKD progression. However, its role in kidney function decline in the general population is unknown. We assessed the relationship between baseline (1990-1992) serum levels of intact fibroblast growth factor-23 and incident ESRD in 13,448 Atherosclerosis Risk in Communities study participants (56.1% women, 74.7% white) followed until December 31, 2010. At baseline, the mean age of participants was 56.9 years and the mean eGFR was 97 ml/min per 1.73 m(2). During a median follow-up of 19 years, 267 participants (2.0%) developed ESRD. After adjustment for demographic characteristics, baseline eGFR, traditional CKD risk factors, and markers of mineral metabolism, the highest fibroblast growth factor-23 quintile (>54.6 pg/ml) compared with the lowest quintile ( |
DOI | 10.1681/ASN.2014020218 |
Alternate Journal | J Am Soc Nephrol |
PubMed ID | 25060052 |
PubMed Central ID | PMC4279743 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States R01 HL103706 / HL / NHLBI NIH HHS / United States U01 DK085660 / DK / NIDDK NIH HHS / United States U01-DK085689 / DK / NIDDK NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States U01-DK085660 / DK / NIDDK NIH HHS / United States U01-DK085649 / DK / NIDDK NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States U01-DK085688 / DK / NIDDK NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States U01 DK085673 / DK / NIDDK NIH HHS / United States U01 DK085651 / DK / NIDDK NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States T32-HL007024 / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States U01 DK085649 / DK / NIDDK NIH HHS / United States U01 DK085689 / DK / NIDDK NIH HHS / United States R01-HL103706 / HL / NHLBI NIH HHS / United States U01-DK085673 / DK / NIDDK NIH HHS / United States U01-DK085651 / DK / NIDDK NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States R01-DK089174 / DK / NIDDK NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States U01 DK085688 / DK / NIDDK NIH HHS / United States |