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Serum fibroblast growth factor-23 is associated with incident kidney disease.

TitleSerum fibroblast growth factor-23 is associated with incident kidney disease.
Publication TypeJournal Article
Year of Publication2015
AuthorsRebholz CM, Grams ME, Coresh JJ, Selvin E, Inker LA, Levey AS, Kimmel PL, Vasan RS, Eckfeldt JH, Feldman HI, Hsu C-Y
Secondary AuthorsLutsey PL
Corporate AuthorsChronic Kidney Disease Biomarkers Consortium
JournalJ Am Soc Nephrol
Volume26
Issue1
Pagination192-200
Date Published2015 Jan
ISSN1533-3450
KeywordsAdult, Age Factors, Aged, Atherosclerosis, Cohort Studies, Disease Progression, Female, Fibroblast Growth Factors, Gene Expression Regulation, Glomerular Filtration Rate, Humans, Kidney Diseases, Male, Middle Aged, Risk Factors, Sex Factors, Vitamin D
Abstract

Fibroblast growth factor-23 is a bone-derived hormone that increases urinary phosphate excretion and inhibits hydroxylation of 25-hydroxyvitamin D. Recent studies suggest that fibroblast growth factor-23 may be an early biomarker of CKD progression. However, its role in kidney function decline in the general population is unknown. We assessed the relationship between baseline (1990-1992) serum levels of intact fibroblast growth factor-23 and incident ESRD in 13,448 Atherosclerosis Risk in Communities study participants (56.1% women, 74.7% white) followed until December 31, 2010. At baseline, the mean age of participants was 56.9 years and the mean eGFR was 97 ml/min per 1.73 m(2). During a median follow-up of 19 years, 267 participants (2.0%) developed ESRD. After adjustment for demographic characteristics, baseline eGFR, traditional CKD risk factors, and markers of mineral metabolism, the highest fibroblast growth factor-23 quintile (>54.6 pg/ml) compared with the lowest quintile (

DOI10.1681/ASN.2014020218
Alternate JournalJ Am Soc Nephrol
PubMed ID25060052
PubMed Central IDPMC4279743
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 HL103706 / HL / NHLBI NIH HHS / United States
U01 DK085660 / DK / NIDDK NIH HHS / United States
U01-DK085689 / DK / NIDDK NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
U01-DK085660 / DK / NIDDK NIH HHS / United States
U01-DK085649 / DK / NIDDK NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
U01-DK085688 / DK / NIDDK NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
U01 DK085673 / DK / NIDDK NIH HHS / United States
U01 DK085651 / DK / NIDDK NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
T32-HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
U01 DK085649 / DK / NIDDK NIH HHS / United States
U01 DK085689 / DK / NIDDK NIH HHS / United States
R01-HL103706 / HL / NHLBI NIH HHS / United States
U01-DK085673 / DK / NIDDK NIH HHS / United States
U01-DK085651 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
R01-DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
U01 DK085688 / DK / NIDDK NIH HHS / United States