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The metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC).

TitleThe metabolic syndrome and cognitive decline in the Atherosclerosis Risk in Communities study (ARIC).
Publication TypeJournal Article
Year of Publication2014
AuthorsDearborn JL, Knopman D, Sharrett ARichey, Schneider ALC, Jack CR, Coker LH, Alonso A, Selvin E, Mosley TH, Wagenknecht LE, Windham BG
Secondary AuthorsGottesman RF
JournalDement Geriatr Cogn Disord
Volume38
Issue5-6
Pagination337-46
Date Published2014
ISSN1421-9824
KeywordsCognition Disorders, Female, Humans, Longitudinal Studies, Male, Metabolic Syndrome, Middle Aged, Prospective Studies, Risk Factors
Abstract

BACKGROUND: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components.

METHODS: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit).

RESULTS: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference).

CONCLUSIONS: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life.

DOI10.1159/000362265
Alternate JournalDement Geriatr Cogn Disord
PubMed ID25171458
PubMed Central IDPMC4201882
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States