|Title||Echocardiographic measures of cardiac structure and function are associated with risk of atrial fibrillation in blacks: the Atherosclerosis Risk in Communities (ARIC) study.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Bekwelem W, Misialek JR, Konety S, Solomon SD, Soliman EZ, Loehr LR, Norby FL, Fox ER, Mosley TH|
|Secondary Authors||Alonso A|
|Keywords||African Continental Ancestry Group, Aged, Atherosclerosis, Atrial Fibrillation, Echocardiography, Female, Heart, Humans, Male, Middle Aged, Organ Size, Residence Characteristics, Risk Factors|
BACKGROUND: Several studies have examined the link between atrial fibrillation (AF) and various echocardiographic measures of cardiac structure and function in whites and other racial groups but not in blacks. Exploring AF risk factors in blacks is important given that the lower incidence of AF in this racial group despite higher risk factors, is not completely explained.
METHODS: We examined the association of echocardiographic measures with AF incidence in 2283 blacks (64.5% women, mean age 58.8 years) free of diagnosed AF and enrolled in the Jackson cohort of Atherosclerosis Risk in Communities (ARIC) study, a prospective study of cardiovascular disease. Echocardiography was performed in 1993-1995, and incident AF was determined by electrocardiograms at a follow-up study exam, hospitalization discharge codes and death certificates through the end of 2009. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals for AF associated with the echocardiographic measures, adjusting for age, sex, and known AF risk factors.
RESULTS: During an average follow-up of 13.5 years, 191 (8.4%) individuals developed AF. Left ventricular (LV) internal diameter 2-D (diastole) and percent fractional shortening of LV diameter displayed a U-shaped relationship with risk of AF, while left atrial diameter displayed a J-shaped nonlinear association. LV mass index was associated positively with AF. E/A ratio 1.5 and ejection fraction (EF
CONCLUSIONS: In a community-based population of blacks, echocardiographic measures of cardiac structure and function are significantly associated with an increased risk of AF.
|Alternate Journal||PLoS One|
|PubMed Central ID||PMC4199625|
|Grant List||HHSN268201100005C / / PHS HHS / United States |
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
RC1-HL099452 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States