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Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study.

TitleAdiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2014
AuthorsDearborn JL, Schneider ALC, Gottesman RF, Kurth T, Pankow JS, Couper DJ, Rose KM, Williams MA
Secondary AuthorsB Peterlin L
JournalNeurology
Volume83
Issue24
Pagination2211-8
Date Published2014 Dec 09
ISSN1526-632X
KeywordsAdiponectin, Atherosclerosis, Blood Chemical Analysis, Case-Control Studies, Female, Humans, Leptin, Logistic Models, Longitudinal Studies, Male, Middle Aged, Migraine Disorders, Odds Ratio, Prevalence, Prospective Studies, Risk, Sex Factors, Surveys and Questionnaires
Abstract

OBJECTIVE: To evaluate adiponectin and leptin levels in older men and women with migraine.

METHODS: Fasting total and high molecular weight (HMW) adiponectin and leptin levels were evaluated in a case-cohort study of nondiabetic older migraine and nonmigraine control participants from the ongoing, longitudinal, general population, Atherosclerosis Risk in Communities Study at visit 1 (1987-1989). A standardized headache questionnaire was completed at visit 3 (1993-1995). Logistic regression models adjusted for age, sex, race, center, body mass index, and fasting glucose were used to evaluate the association of each adipocytokine with migraine.

RESULTS: Of the 981 participants, the mean age at baseline was 52.8 years (SE 0.3); 131 fulfilled migraine criteria. Crude, mean total adiponectin levels were greater in men and women with migraine (8.1 µg/mL, SE 0.5) as compared to those without migraine (7.0 µg/mL, SE 0.2) (p = 0.031). After adjustments, the odds of migraine were increased by 88% with each SD increase in total adiponectin in men (odds ratio [OR] 1.86; 95% confidence interval [CI] 1.15, 3.01; p = 0.011), but not in women (OR 1.05; 95% CI 0.80, 1.37; p = 0.728; p interaction = 0.029). Similar results were demonstrated for HMW adiponectin. Crude and adjusted leptin levels were not associated with migraine.

CONCLUSIONS: Although crude, total adiponectin levels were higher in older men and women with migraine than controls, after adjustments, the prevalence of migraine was significantly associated with total adiponectin only in older men, suggesting the association may be confounded or absent in older women. Leptin was not associated with migraine in older men or women.

DOI10.1212/WNL.0000000000001067
Alternate JournalNeurology
PubMed ID25378672
PubMed Central IDPMC4277678
Grant ListHHSN268201100005C / / PHS HHS / United States
K23 NS078345 / NS / NINDS NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
HHSN268201100007C / / PHS HHS / United States
R01-DK56918 / DK / NIDDK NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States