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Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study.

TitleTelomere length attrition and chronic periodontitis: an ARIC Study nested case-control study.
Publication TypeJournal Article
Year of Publication2015
AuthorsSanders AE, Divaris K, Naorungroj S, Heiss G
Secondary AuthorsRisques RA
JournalJ Clin Periodontol
Volume42
Issue1
Pagination12-20
Date Published2015 Jan
ISSN1600-051X
KeywordsAfrican Americans, Aged, Case-Control Studies, Chronic Periodontitis, Cohort Studies, Diabetes Complications, DNA, Educational Status, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Hypertension, Income, Leukocytes, Male, Middle Aged, Obesity, Prospective Studies, Protein-Serine-Threonine Kinases, Ribosomal Proteins, Sex Factors, Smoking, Telomere Shortening, Tooth Loss
Abstract

AIM: This nested case-control study sought to determine whether an accelerated rate of leukocyte telomere length (LTL) shortening over 6 years was associated with chronic periodontitis.

MATERIALS AND METHODS: We sampled cases (n = 178) with severe chronic periodontitis and controls (n = 178) with no/mild chronic periodontitis from the Atherosclerosis Risk in Communities study. Controls were frequency-matched to cases by study site, age, sex and race. Age ranged from 53 to 73 years. Severe chronic periodontitis was defined using the CDC-AAP case classification. LTL was measured from DNA collected at two time points, 6 years apart, with quantitative polymerase chain reaction relative to a single-copy control gene. Multiple linear regression evaluated associations between LTL measured at baseline, follow-up and change scores with severe chronic periodontitis, adjusting for potential confounders.

RESULTS: Cases had shorter LTL than controls at baseline (p = 0.03) and follow-up (p = 0.04) after adjusting for confounding. Overall there was a net reduction in LTL over time (p = 0.02). The rate of LTL did not differ between cases and controls (p = 0.80).

CONCLUSIONS: Leukocyte telomere length shortening occurred at the same rate among adults with and without severe chronic periodontitis. This suggests that LTL shortening may have occurred earlier in the life course.

DOI10.1111/jcpe.12337
Alternate JournalJ Clin Periodontol
PubMed ID25418689
PubMed Central IDPMC4444215
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 DE011551 / DE / NIDCR NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01-DE11551 / DE / NIDCR NIH HHS / United States
R03 DE022555 / DE / NIDCR NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
R03-DE022555 / DE / NIDCR NIH HHS / United States