Title | Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Sanders AE, Divaris K, Naorungroj S, Heiss G |
Secondary Authors | Risques RA |
Journal | J Clin Periodontol |
Volume | 42 |
Issue | 1 |
Pagination | 12-20 |
Date Published | 2015 Jan |
ISSN | 1600-051X |
Keywords | African Americans, Aged, Case-Control Studies, Chronic Periodontitis, Cohort Studies, Diabetes Complications, DNA, Educational Status, European Continental Ancestry Group, Female, Follow-Up Studies, Humans, Hypertension, Income, Leukocytes, Male, Middle Aged, Obesity, Prospective Studies, Protein-Serine-Threonine Kinases, Ribosomal Proteins, Sex Factors, Smoking, Telomere Shortening, Tooth Loss |
Abstract | AIM: This nested case-control study sought to determine whether an accelerated rate of leukocyte telomere length (LTL) shortening over 6 years was associated with chronic periodontitis. MATERIALS AND METHODS: We sampled cases (n = 178) with severe chronic periodontitis and controls (n = 178) with no/mild chronic periodontitis from the Atherosclerosis Risk in Communities study. Controls were frequency-matched to cases by study site, age, sex and race. Age ranged from 53 to 73 years. Severe chronic periodontitis was defined using the CDC-AAP case classification. LTL was measured from DNA collected at two time points, 6 years apart, with quantitative polymerase chain reaction relative to a single-copy control gene. Multiple linear regression evaluated associations between LTL measured at baseline, follow-up and change scores with severe chronic periodontitis, adjusting for potential confounders. RESULTS: Cases had shorter LTL than controls at baseline (p = 0.03) and follow-up (p = 0.04) after adjusting for confounding. Overall there was a net reduction in LTL over time (p = 0.02). The rate of LTL did not differ between cases and controls (p = 0.80). CONCLUSIONS: Leukocyte telomere length shortening occurred at the same rate among adults with and without severe chronic periodontitis. This suggests that LTL shortening may have occurred earlier in the life course. |
DOI | 10.1111/jcpe.12337 |
Alternate Journal | J Clin Periodontol |
PubMed ID | 25418689 |
PubMed Central ID | PMC4444215 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States R01 DE011551 / DE / NIDCR NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100005C / / PHS HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100009C / / PHS HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100010C / / PHS HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100008C / / PHS HHS / United States HHSN268201100012C / / PHS HHS / United States R01-DE11551 / DE / NIDCR NIH HHS / United States R03 DE022555 / DE / NIDCR NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100007C / / PHS HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100011C / / PHS HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States HHSN268201100006C / / PHS HHS / United States R03-DE022555 / DE / NIDCR NIH HHS / United States |