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Bundle branch blocks and the risk of mortality in the Atherosclerosis Risk in Communities study.

TitleBundle branch blocks and the risk of mortality in the Atherosclerosis Risk in Communities study.
Publication TypeJournal Article
Year of Publication2016
AuthorsZhang Z-M, Rautaharju PM, Prineas RJ, Loehr LR, Rosamond WD
Secondary AuthorsSoliman EZ
JournalJ Cardiovasc Med (Hagerstown)
Date Published2016 Jun
KeywordsAtherosclerosis, Brugada Syndrome, Bundle-Branch Block, Cardiac Conduction System Disease, Coronary Artery Disease, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Risk Assessment, United States

AIMS: The main objective of our study was to evaluate the associations between different categories of bundle branch blocks (BBBs) and mortality and to consider possible impact of QRS prolongation in these associations.

METHODS: This analysis included 15 408 participants (mean age 54 years, 55.2% women, and 26.9% blacks) from the Atherosclerosis Risk in Communities study. We used Cox regression to examine associations between left BBB (LBBB), right BBB (RBBB) and indetermined type of ventricular conduction defect [intraventricular conduction defect (IVCD)] with coronary heart disease (CHD) death and all-cause mortality.

RESULTS: During a mean 21 years of follow-up, 4767 deaths occurred; of these, 728 were CHD deaths. Compared to No-BBB, LBBB and IVCD were strongly associated with increased CHD death (hazard ratios 4.11 and 3.18, respectively; P 

CONCLUSION: Prevalent LBBB and IVCD, but not RBBB, are associated with increased risk of CHD death and all-cause mortality. Mortality risk is further increased as the QRS duration is prolonged above 140 ms.

Alternate JournalJ Cardiovasc Med (Hagerstown)
PubMed ID25575277