| Title | New genetic loci link adipose and insulin biology to body fat distribution. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Shungin D, Winkler TW, Croteau-Chonka DC, et al. |
| Secondary Authors | Mohlke KL |
| Corporate Authors | ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, GLGC, ICBP, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium |
| Journal | Nature |
| Volume | 518 |
| Issue | 7538 |
| Pagination | 187-196 |
| Date Published | 2015 Feb 12 |
| ISSN | 1476-4687 |
| Keywords | Adipocytes, Adipogenesis, Adipose Tissue, Age Factors, Body Fat Distribution, Body Mass Index, Continental Population Groups, Epigenesis, Genetic, Europe, Female, Genome, Human, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Male, Models, Biological, Neovascularization, Physiologic, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Sex Characteristics, Transcription, Genetic, Waist-Hip Ratio |
| Abstract | Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P |
| DOI | 10.1038/nature14132 |
| Alternate Journal | Nature |
| PubMed ID | 25673412 |
| PubMed Central ID | PMC4338562 |
| Grant List | R01 HL120393 / HL / NHLBI NIH HHS / United States 085235 / WT_ / Wellcome Trust / United Kingdom R01 DK075787 / DK / NIDDK NIH HHS / United States MRC_MC_UP_A620_1014 / MRC_ / Medical Research Council / United Kingdom R01 DK093757 / DK / NIDDK NIH HHS / United States U01 HG007417 / HG / NHGRI NIH HHS / United States MC_UU_12012/1 / MRC_ / Medical Research Council / United Kingdom BHF_RG/13/2/30098 / BHF_ / British Heart Foundation / United Kingdom CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom G9521010 / MRC_ / Medical Research Council / United Kingdom G1001799 / MRC_ / Medical Research Council / United Kingdom G0601463 / MRC_ / Medical Research Council / United Kingdom R21 DA027040 / DA / NIDA NIH HHS / United States K23 DK080145 / DK / NIDDK NIH HHS / United States 098017 / WT_ / Wellcome Trust / United Kingdom RG/13/2/30098 / BHF_ / British Heart Foundation / United Kingdom P30 DK040561 / DK / NIDDK NIH HHS / United States U01 HG007419 / HG / NHGRI NIH HHS / United States RG/08/008/25291 / BHF_ / British Heart Foundation / United Kingdom WT097117 / WT_ / Wellcome Trust / United Kingdom MC_U147585827 / MRC_ / Medical Research Council / United Kingdom BHF_RG/08/014/24067 / BHF_ / British Heart Foundation / United Kingdom R01 HL109946 / HL / NHLBI NIH HHS / United States MC_UP_A100_1003 / MRC_ / Medical Research Council / United Kingdom MRC_MC_UU_12012/1 / MRC_ / Medical Research Council / United Kingdom WT098498 / WT_ / Wellcome Trust / United Kingdom 12/0004470 / DUK_ / Diabetes UK / United Kingdom G19/35 / MRC_ / Medical Research Council / United Kingdom T32 GM067553 / GM / NIGMS NIH HHS / United States G0100222 / MRC_ / Medical Research Council / United Kingdom MRC_MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom U01 HG007416 / HG / NHGRI NIH HHS / United States MRC_G1001799 / MRC_ / Medical Research Council / United Kingdom WT084766 / WT_ / Wellcome Trust / United Kingdom RG/08/014/24067 / BHF_ / British Heart Foundation / United Kingdom MRC_G9521010 / MRC_ / Medical Research Council / United Kingdom R01 DK072193 / DK / NIDDK NIH HHS / United States P30 DK079637 / DK / NIDDK NIH HHS / United States MRC_G0401527 / MRC_ / Medical Research Council / United Kingdom MRC_MC_UU_12015/5 / MRC_ / Medical Research Council / United Kingdom MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom G8802774 / MRC_ / Medical Research Council / United Kingdom P30 DK056341 / DK / NIDDK NIH HHS / United States MC_U147585819 / MRC_ / Medical Research Council / United Kingdom G1000143 / MRC_ / Medical Research Council / United Kingdom U01 HG007376 / HG / NHGRI NIH HHS / United States Z01 HG000024-14 / ImNIH / Intramural NIH HHS / United States WT098381 / WT_ / Wellcome Trust / United Kingdom G0902037 / MRC_ / Medical Research Council / United Kingdom MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom R01 AG025941 / AG / NIA NIH HHS / United States R01 AG041517 / AG / NIA NIH HHS / United States MRC_MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom U54 HD083211 / HD / NICHD NIH HHS / United States MC_UU_12015/1 / MRC_ / Medical Research Council / United Kingdom R01 DK107437 / DK / NIDDK NIH HHS / United States MRC_MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom MC_UP_A620_1014 / MRC_ / Medical Research Council / United Kingdom R01 DK062370 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States MC_U106179471 / MRC_ / Medical Research Council / United Kingdom MR/N01104X/1 / MRC_ / Medical Research Council / United Kingdom CSO_CZB/4/710 / CSO_ / Chief Scientist Office / United Kingdom 097117 / WT_ / Wellcome Trust / United Kingdom WT098017 / WT_ / Wellcome Trust / United Kingdom MC_UU_12015/2 / MRC_ / Medical Research Council / United Kingdom 098498 / WT_ / Wellcome Trust / United Kingdom P20 MD006899 / MD / NIMHD NIH HHS / United States P30 DK072488 / DK / NIDDK NIH HHS / United States K01 HL116770 / HL / NHLBI NIH HHS / United States 14136 / CRUK_ / Cancer Research UK / United Kingdom R01 AG033193 / AG / NIA NIH HHS / United States G1000616 / MRC_ / Medical Research Council / United Kingdom MRC_MC_UP_A100_1003 / MRC_ / Medical Research Council / United Kingdom MC_U106179472 / MRC_ / Medical Research Council / United Kingdom G0401527 / MRC_ / Medical Research Council / United Kingdom MRC_G0601261 / MRC_ / Medical Research Council / United Kingdom MC_UU_12013/1 / MRC_ / Medical Research Council / United Kingdom BHF_RG/08/008/25291 / BHF_ / British Heart Foundation / United Kingdom R00 HL094535 / HL / NHLBI NIH HHS / United States P30 DK020541 / DK / NIDDK NIH HHS / United States MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom UM1 CA182913 / CA / NCI NIH HHS / United States U01 DK062370 / DK / NIDDK NIH HHS / United States G0600717 / MRC_ / Medical Research Council / United Kingdom WT100574 / WT_ / Wellcome Trust / United Kingdom T32 GM007092 / GM / NIGMS NIH HHS / United States MRC_MC_UU_12013/1 / MRC_ / Medical Research Council / United Kingdom 084766 / WT_ / Wellcome Trust / United Kingdom MRC_MR/N01104X/1 / MRC_ / Medical Research Council / United Kingdom 100574 / WT_ / Wellcome Trust / United Kingdom MRC_G0601463 / MRC_ / Medical Research Council / United Kingdom MRC_MC_U106179472 / MRC_ / Medical Research Council / United Kingdom FS/14/55/30806 / BHF_ / British Heart Foundation / United Kingdom P30 GM103341 / GM / NIGMS NIH HHS / United States R01 DK089256 / DK / NIDDK NIH HHS / United States MR/K006584/1 / MRC_ / Medical Research Council / United Kingdom MR/K013351/1 / MRC_ / Medical Research Council / United Kingdom MC_UU_12011/1 / MRC_ / Medical Research Council / United Kingdom BHF_FS/14/55/30806 / BHF_ / British Heart Foundation / United Kingdom MRC_MC_U106179471 / MRC_ / Medical Research Council / United Kingdom CRUK_14136 / CRUK_ / Cancer Research UK / United Kingdom T32 HL069768 / HL / NHLBI NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States MC_UU_12015/5 / MRC_ / Medical Research Council / United Kingdom MRC_MR/K013351/1 / MRC_ / Medical Research Council / United Kingdom P60 DK020541 / DK / NIDDK NIH HHS / United States R01 HL117626 / HL / NHLBI NIH HHS / United States 098381 / WT_ / Wellcome Trust / United Kingdom R01 HL117078 / HL / NHLBI NIH HHS / United States WT085235 / WT_ / Wellcome Trust / United Kingdom MRC_G1000143 / MRC_ / Medical Research Council / United Kingdom MR/K011480/1 / MRC_ / Medical Research Council / United Kingdom G0400491 / MRC_ / Medical Research Council / United Kingdom UM1 CA182910 / CA / NCI NIH HHS / United States T32 HL007055 / HL / NHLBI NIH HHS / United States MRC_MR/L003120/1 / MRC_ / Medical Research Council / United Kingdom G0601261 / MRC_ / Medical Research Council / United Kingdom P30 CA071789 / CA / NCI NIH HHS / United States MRC_MC_UU_12011/1 / MRC_ / Medical Research Council / United Kingdom MC_U147585824 / MRC_ / Medical Research Council / United Kingdom MRC_MC_UU_12019/1 / MRC_ / Medical Research Council / United Kingdom BHF_RG/10/12/28456 / BHF_ / British Heart Foundation / United Kingdom R01 DK078150 / DK / NIDDK NIH HHS / United States DUK_12/0004470 / DUK_ / Diabetes UK / United Kingdom MRC_MR/K006584/1 / MRC_ / Medical Research Council / United Kingdom MRC_MR/K011480/1 / MRC_ / Medical Research Council / United Kingdom U01 AG049505 / AG / NIA NIH HHS / United States RG/07/008/23674 / BHF_ / British Heart Foundation / United Kingdom RG/10/12/28456 / BHF_ / British Heart Foundation / United Kingdom |