Pulse lineResearch With Heart Logo

Association of hospitalization with long-term cognitive and brain MRI changes in the ARIC cohort.

TitleAssociation of hospitalization with long-term cognitive and brain MRI changes in the ARIC cohort.
Publication TypeJournal Article
Year of Publication2015
AuthorsBrown CH, Sharrett ARichey, Coresh JJ, Schneider ALC, Alonso A, Knopman DS, Mosley TH
Secondary AuthorsGottesman RF
JournalNeurology
Volume84
Issue14
Pagination1443-53
Date Published2015 Apr 07
ISSN1526-632X
KeywordsAged, Cerebral Ventricles, Cognition Disorders, Female, Follow-Up Studies, Hospitalization, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mississippi, Neuropsychological Tests, North Carolina, Time Factors
Abstract

OBJECTIVE: To determine whether hospitalization is associated with subsequent cognitive decline or changes on brain MRI in a community-based cohort.

METHODS: Baseline and follow-up cognitive testing (n = 2,386) and MRI scans with standardized assessments (n = 885) were available from a subset of white and black participants in the Atherosclerosis Risk in Communities study. Cognitive tests included the Delayed Word Recall Test (DWRT), Digit Symbol Substitution Test (DSST), and Word Fluency Test (WFT). Hospitalization characteristics were determined using ICD-9 codes. Regression models adjusted for demographics, education, comorbidities, and APOE Īµ4 were used to estimate the independent association of hospitalization with changes in cognition or neuroimaging.

RESULTS: Over a mean 14.1 years between visits, 1,266 participants (53.1%) were hospitalized. Hospitalization compared with no hospitalization was associated with greater decline in DSST scores (1.25 points greater decline, p

CONCLUSIONS: Cognitive decline and neuroimaging changes may occur after hospitalization, independent of baseline demographics and comorbidities.

DOI10.1212/WNL.0000000000001439
Alternate JournalNeurology
PubMed ID25762715
PubMed Central IDPMC4395884
Grant ListUL1RR025005 / RR / NCRR NIH HHS / United States
HL096899 / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
R01HL59367 / HL / NHLBI NIH HHS / United States
HL096902 / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
HHSN268200625226C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
R01-HL70825 / HL / NHLBI NIH HHS / United States
HHSN268201100012C / / PHS HHS / United States
R01HL087641 / HL / NHLBI NIH HHS / United States
HL096814 / HL / NHLBI NIH HHS / United States
5T32HL007024 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
R01 AG033615-01A1 / AG / NIA NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
U01HL075572-01 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
R03 AG042331 / AG / NIA NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States