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25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study.

Title25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study.
Publication TypeJournal Article
Year of Publication2015
AuthorsMichos ED, Misialek JR, Selvin E, Folsom AR, Pankow JS, Post WS
Secondary AuthorsLutsey PL
JournalAtherosclerosis
Volume241
Issue1
Pagination12-7
Date Published2015 Jul
ISSN1879-1484
KeywordsAfrican Americans, Biomarkers, Comorbidity, Coronary Disease, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, Health Status Disparities, Humans, Incidence, Linear Models, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prospective Studies, Risk Factors, Time Factors, United States, Vitamin D, Vitamin D Deficiency, Vitamin D-Binding Protein
Abstract

BACKGROUND: In observational studies, low 25-hydroxyvitamin D (25(OH)D) has been associated with increased risk of coronary heart disease (CHD), and this association may vary by race. Racial differences in the frequency of vitamin D binding protein (DBP) single nucleotide polymorphisms (SNPs) might account for similar bioavailable vitamin D in blacks despite lower mean 25(OH)D. We hypothesized that the associations of low 25(OH)D with CHD risk would be stronger among whites and among persons with genotypes associated with higher DBP levels.

METHODS: We measured 25(OH)D by mass spectroscopy in 11,945 participants in the ARIC Study (baseline 1990-1992, mean age 57 years, 59% women, 24% black). Two DBP SNPs (rs7041; rs4588) were genotyped. We used adjusted Cox proportional hazards models to examine the association of 25(OH)D with adjudicated CHD events through December 2011.

RESULTS: Over a median of 20 years, there were 1230 incident CHD events. Whites in the lowest quintile of 25(OH)D (

CONCLUSIONS: Low 25(OH)D was associated with incident CHD in whites, but no interactions of 25(OH)D with key DBP genotypes was found.

DOI10.1016/j.atherosclerosis.2015.04.803
Alternate JournalAtherosclerosis
PubMed ID25941991
PubMed Central IDPMC4466162
Grant ListR01 HL103706 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
R01HL103706 / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 NS072243 / NS / NINDS NIH HHS / United States
R01HL103706-S1 / HL / NHLBI NIH HHS / United States
R01DK089174 / DK / NIDDK NIH HHS / United States
N01 HC065226 / HC / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
R01NS072243 / NS / NINDS NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC65226 / HC / NHLBI NIH HHS / United States