Title | Racial differences in circulating natriuretic peptide levels: the atherosclerosis risk in communities study. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Gupta DK, Claggett B, Wells Q, Cheng S, Li M, Maruthur N, Selvin E, Coresh JJ, Konety S, Butler KR, Mosley T, Boerwinkle E, Hoogeveen RC, Ballantyne CM |
Secondary Authors | Solomon SD |
Journal | J Am Heart Assoc |
Volume | 4 |
Issue | 5 |
Date Published | 2015 May 21 |
ISSN | 2047-9980 |
Keywords | African Americans, Atherosclerosis, European Continental Ancestry Group, Female, Humans, Hypertension, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Residence Characteristics, Risk Factors |
Abstract | BACKGROUND: Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community-based cohorts are lacking. METHODS AND RESULTS: We examined plasma N-terminal pro B-type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996-1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P CONCLUSIONS: African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population. |
DOI | 10.1161/JAHA.115.001831 |
Alternate Journal | J Am Heart Assoc |
PubMed ID | 25999400 |
PubMed Central ID | PMC4599412 |
Grant List | T32 HL094301 / HL / NHLBI NIH HHS / United States UL1TR000445 / TR / NCATS NIH HHS / United States HHSN268201100005C / / PHS HHS / United States HHSN268201100009C / / PHS HHS / United States HHSN268201100010C / / PHS HHS / United States K12HL109019 / HL / NHLBI NIH HHS / United States R00 HL107642 / HL / NHLBI NIH HHS / United States HHSN268201100008C / / PHS HHS / United States HHSN268201100012C / / PHS HHS / United States K12 HL109019 / HL / NHLBI NIH HHS / United States HHSN268201100007C / / PHS HHS / United States HHSN268201100011C / / PHS HHS / United States HHSN268201100006C / / PHS HHS / United States |