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Racial differences in circulating natriuretic peptide levels: the atherosclerosis risk in communities study.

TitleRacial differences in circulating natriuretic peptide levels: the atherosclerosis risk in communities study.
Publication TypeJournal Article
Year of Publication2015
AuthorsGupta DK, Claggett B, Wells Q, Cheng S, Li M, Maruthur N, Selvin E, Coresh JJ, Konety S, Butler KR, Mosley T, Boerwinkle E, Hoogeveen RC, Ballantyne CM
Secondary AuthorsSolomon SD
JournalJ Am Heart Assoc
Volume4
Issue5
Date Published2015 May 21
ISSN2047-9980
KeywordsAfrican Americans, Atherosclerosis, European Continental Ancestry Group, Female, Humans, Hypertension, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Residence Characteristics, Risk Factors
Abstract

BACKGROUND: Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community-based cohorts are lacking.

METHODS AND RESULTS: We examined plasma N-terminal pro B-type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996-1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P

CONCLUSIONS: African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population.

DOI10.1161/JAHA.115.001831
Alternate JournalJ Am Heart Assoc
PubMed ID25999400
PubMed Central IDPMC4599412
Grant ListT32 HL094301 / HL / NHLBI NIH HHS / United States
UL1TR000445 / TR / NCATS NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
HHSN268201100009C / / PHS HHS / United States
HHSN268201100010C / / PHS HHS / United States
K12HL109019 / HL / NHLBI NIH HHS / United States
R00 HL107642 / HL / NHLBI NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
K12 HL109019 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
HHSN268201100011C / / PHS HHS / United States
HHSN268201100006C / / PHS HHS / United States