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Relationship between alcohol consumption and cardiac structure and function in the elderly: the Atherosclerosis Risk In Communities Study.

TitleRelationship between alcohol consumption and cardiac structure and function in the elderly: the Atherosclerosis Risk In Communities Study.
Publication TypeJournal Article
Year of Publication2015
AuthorsGonçalves A, Jhund PS, Claggett B, Shah AM, Konety S, Butler K, Kitzman DW, Rosamond WD, Fuchs FD
Secondary AuthorsSolomon SD
JournalCirc Cardiovasc Imaging
Volume8
Issue6
Date Published2015 Jun
ISSN1942-0080
KeywordsAged, Alcohol Drinking, Atherosclerosis, Cardiomyopathies, Causality, Comorbidity, Female, Heart, Heart Atria, Heart Ventricles, Humans, Male, Prospective Studies, Risk, Risk Factors, Sex Factors, Stroke Volume, Ultrasonography, United States, Ventricular Dysfunction, Left
Abstract

BACKGROUND: Excessive alcohol consumption is associated with cardiomyopathy, but the influence of moderate alcohol use on cardiac structure and function is largely unknown.

METHODS AND RESULTS: We studied 4466 participants from visit 5 of the Atherosclerosis Risk in Communities (ARIC) study (76±5 years and 60% women) who underwent transthoracic echocardiography, excluding former drinkers and those with significant valvular disease. Participants were classified into 4 categories based on self-reported alcohol intake: nondrinkers, drinkers of ≤7, ≥7 to 14, and ≥14 drinks per week. We related alcohol intake to measures of cardiac structure and function, stratified by sex, and fully adjusted for covariates. In both genders, increasing alcohol intake was associated with larger left ventricular diastolic and systolic diameters and larger left atrial diameter (P

CONCLUSIONS: In an elderly community-based population, increasing alcohol intake is associated with subtle alterations in cardiac structure and function, with women appearing more susceptible than men to the cardiotoxic effects of alcohol.

DOI10.1161/CIRCIMAGING.114.002846
Alternate JournalCirc Cardiovasc Imaging
PubMed ID26015266
PubMed Central IDPMC4458702
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
K08 HL116792 / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States