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Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.

TitleGenetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.
Publication TypeJournal Article
Year of Publication2015
AuthorsJansen H, Loley C, Lieb W, Pencina MJ, Nelson CP, Kathiresan S, Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E, Hengstenberg C, Laaksonen R, McPherson R, Roberts R, Thorsteinsdottir U, Peters A, Gieger C, Rawal R, Thompson JR, König IR, Vasan RS, Erdmann J, Samani NJ
Secondary AuthorsSchunkert H
Corporate AuthorsCARDIoGRAM Consortium
JournalAtherosclerosis
Volume241
Issue2
Pagination419-26
Date Published2015 Aug
ISSN1879-1484
KeywordsCase-Control Studies, Comorbidity, Coronary Artery Disease, Databases, Genetic, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Europe, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, North America, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors
Abstract

BACKGROUND: The mechanisms underlying the association between diabetes and coronary artery disease (CAD) risk are unclear. We aimed to assess this association by studying genetic variants that have been shown to associate with type 2 diabetes (T2DM). If the association between diabetes and CAD is causal, we expected to observe an association of these variants with CAD as well.

METHODS AND RESULTS: We studied all genetic variants currently known to be associated with T2DM at a genome-wide significant level (p 1, p 

CONCLUSIONS: Our data indicate that an association between type 2 diabetes related SNPs and CAD exists. However, the effects on CAD risk appear to be by far lower than what would be expected based on the effects of risk alleles on T2DM and the effect of T2DM on CAD in the epidemiological setting.

DOI10.1016/j.atherosclerosis.2015.05.033
Alternate JournalAtherosclerosis
PubMed ID26074316
PubMed Central IDPMC4536952
Grant ListN01 HC055022 / HC / NHLBI NIH HHS / United States
R01 HL089650 / HL / NHLBI NIH HHS / United States
R01 HL087647 / HL / NHLBI NIH HHS / United States
R01 HL107816 / HL / NHLBI NIH HHS / United States
R01 HL103931 / HL / NHLBI NIH HHS / United States
N01 HC055018 / HC / NHLBI NIH HHS / United States
R01 HL127564 / HL / NHLBI NIH HHS / United States
P01 HL076491 / HL / NHLBI NIH HHS / United States
R01 DK080732 / DK / NIDDK NIH HHS / United States
R01 DK107437 / DK / NIDDK NIH HHS / United States
R01 DK101478 / DK / NIDDK NIH HHS / United States
T32 HL007208 / HL / NHLBI NIH HHS / United States
N01 HC055019 / HC / NHLBI NIH HHS / United States
P01 HL098055 / HL / NHLBI NIH HHS / United States
N01 HC055015 / HC / NHLBI NIH HHS / United States
N01 HC055021 / HC / NHLBI NIH HHS / United States
N01 HC055020 / HC / NHLBI NIH HHS / United States
N01 HC055016 / HC / NHLBI NIH HHS / United States
UL1 TR000371 / TR / NCATS NIH HHS / United States