| Title | Genetics of Plasma Soluble Receptor for Advanced Glycation End-Products and Cardiovascular Outcomes in a Community-based Population: Results from the Atherosclerosis Risk in Communities Study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Maruthur NM, Li M, Halushka MK, Astor BC, Pankow JS, Boerwinkle E, Coresh JJ, Selvin E |
| Secondary Authors | Kao W H L |
| Journal | PLoS One |
| Volume | 10 |
| Issue | 6 |
| Pagination | e0128452 |
| Date Published | 2015 |
| ISSN | 1932-6203 |
| Keywords | African Americans, Alleles, Cardiovascular Diseases, Enzyme-Linked Immunosorbent Assay, European Continental Ancestry Group, Female, Follow-Up Studies, Gene Frequency, Genome-Wide Association Study, Humans, Male, Metagenomics, Middle Aged, Mutation, Missense, Polymorphism, Single Nucleotide, Receptor for Advanced Glycation End Products, Risk Factors, Survival Analysis |
| Abstract | Plasma soluble Receptor for Advanced Glycation End-products (sRAGE) is a strong marker of vascular outcomes although evidence on the direction of association is mixed. Compared to whites, blacks have lower levels of sRAGE. We hypothesized that genetic determinants of sRAGE would help clarify the causal role of sRAGE and the black-white difference in sRAGE levels. We conducted a genome-wide analysis of sRAGE in whites and blacks from the Atherosclerosis Risk in Communities Study. Median plasma sRAGE levels were lower in blacks than whites (728 vs. 1067 pg/ml; P |
| DOI | 10.1371/journal.pone.0128452 |
| Alternate Journal | PLoS One |
| PubMed ID | 26083729 |
| PubMed Central ID | PMC4471120 |
| Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States UL1RR025005 / RR / NCRR NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States R01HL59367 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States U01HG004402 / HG / NHGRI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States R01HL087641 / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States R01 DK076770 / DK / NIDDK NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States R01-DK076770 / DK / NIDDK NIH HHS / United States R01HL086694 / HL / NHLBI NIH HHS / United States |