Title | Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Carty CL, Keene KL, Cheng Y-C, Meschia JF, Chen W-M, Nalls M, Bis JC, Kittner SJ, Rich SS, Tajuddin S, Zonderman AB, Evans MK, Langefeld CD, Gottesman R, Mosley TH, Shahar E, Woo D, Yaffe K, Liu Y, Sale MM, Dichgans M, Malik R, Longstreth WT, Mitchell BD, Psaty BM, Kooperberg C, Reiner A, Worrall BB |
Secondary Authors | Fornage M |
Corporate Authors | COMPASS and METASTROKE Consortia |
Journal | Stroke |
Volume | 46 |
Issue | 8 |
Pagination | 2063-8 |
Date Published | 2015 Aug |
ISSN | 1524-4628 |
Keywords | African Americans, Case-Control Studies, Cohort Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Risk Factors, Stroke |
Abstract | BACKGROUND AND PURPOSE: The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African Americans, despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population Genome-Wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations. METHODS: Using METAL, we conducted meta-analyses of GWAS in 14 746 African Americans (1365 ischemic and 1592 total stroke cases) from COMPASS, and tested genetic variants with P RESULTS: The 15q21.3 locus linked with lipid levels and hypertension was associated with total stroke (rs4471613; P=3.9×10(-8)) in African Americans. Nominal associations (P CONCLUSIONS: We identified a novel genetic variant associated with total stroke in African Americans and found that ischemic stroke loci identified in European-ancestry populations may also be relevant for African Americans. Our findings support investigation of diverse populations to identify and characterize genetic risk factors, and the importance of shared genetic risk across populations. |
DOI | 10.1161/STROKEAHA.115.009044 |
Alternate Journal | Stroke |
PubMed ID | 26089329 |
PubMed Central ID | PMC4740911 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States U01 HG005160 / HG / NHGRI NIH HHS / United States R01 HL103612 / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States R01 NS045012 / NS / NINDS NIH HHS / United States Z01 AG000513 / / Intramural NIH HHS / United States R01 NS042733 / NS / NINDS NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States UL1 RR025005 / RR / NCRR NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States U01 HL080295 / HL / NHLBI NIH HHS / United States P30 CA015704 / CA / NCI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268200800007C / HL / NHLBI NIH HHS / United States R01 NS087541 / NS / NINDS NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R01 HL086694 / HL / NHLBI NIH HHS / United States R01 HL087652 / HL / NHLBI NIH HHS / United States U01 HG004402 / HG / NHGRI NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States N01HC55222 / HL / NHLBI NIH HHS / United States Z01 AG000954 / / Intramural NIH HHS / United States R01 HL093029 / HL / NHLBI NIH HHS / United States N01HC85086 / HL / NHLBI NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States P30 DK063491 / DK / NIDDK NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201200036C / HL / NHLBI NIH HHS / United States P30 DK072488 / DK / NIDDK NIH HHS / United States U01 NS069208 / NS / NINDS NIH HHS / United States R01 NS039987 / NS / NINDS NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States R01 NS034447 / NS / NINDS NIH HHS / United States N01HC85082 / HL / NHLBI NIH HHS / United States U01 HG004436 / HG / NHGRI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States N01HC85083 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States S10 OD020069 / OD / NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States N01HC85079 / HL / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States R01 HL087641 / HL / NHLBI NIH HHS / United States N01HC85080 / HL / NHLBI NIH HHS / United States N01WH22110 / WH / WHI NIH HHS / United States N01HC85081 / HL / NHLBI NIH HHS / United States IK2 BX001823 / BX / BLRD VA / United States |