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Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis.

TitleRetinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis.
Publication TypeJournal Article
Year of Publication2015
AuthorsSabanayagam C, Lye WKit, Klein R, Klein BEK, Cotch M F, Wang J J, Mitchell P, Shaw JE, Selvin E, Sharrett ARichey
Secondary AuthorsWong TY
JournalDiabetologia
Volume58
Issue11
Pagination2476-85
Date Published2015 Nov
ISSN1432-0428
KeywordsDiabetes Mellitus, Type 2, Female, Humans, Incidence, Male, Retinal Vessels, Risk
Abstract

AIMS/HYPOTHESIS: The calibre of the retinal vessels has been linked to diabetes mellitus but studies have not shown consistent results. We conducted a participant-level meta-analysis to evaluate the association between retinal arteriolar and venular calibre and diabetes.

METHODS: We performed a systematic review on MEDLINE and EMBASE for articles published up to December 2014. We identified five population-based prospective cohort studies that provided individual-level data on 18,771 diabetes-free participants. We used discrete time proportional hazards models to estimate pooled HRs of diabetes associated with 1 SD (20 μm) change in retinal vascular calibre.

RESULTS: We identified 2,581 incident cases of diabetes over a median follow-up period of 10 years (interquartile interval of 3.4-15.8 years). After adjustment for demographic, lifestyle and clinical factors, retinal venular calibre was significantly associated with incident diabetes (pooled HR 1.09 [95% CI 1.02, 1.15] per SD increase in venular calibre). This association persisted in analyses excluding individuals with

CONCLUSIONS/INTERPRETATION: Wider retinal venules but not narrower retinal arterioles were associated with a modestly increased risk for diabetes. Knowledge of pathological mechanisms underlying wider retinal venule may provide further insights concerning microvascular alterations in diabetes.

DOI10.1007/s00125-015-3717-2
Alternate JournalDiabetologia
PubMed ID26232097
PubMed Central IDPMC4751991
Grant ListN01-HC-95162 / HC / NHLBI NIH HHS / United States
Z01 EY000426-05 / / Intramural NIH HHS / United States
Z99 EY999999 / / Intramural NIH HHS / United States
ZIA EY000403-13 / / Intramural NIH HHS / United States
ZIA EY000426-10 / / Intramural NIH HHS / United States
HHSN268201100005C / / PHS HHS / United States
U10 EY006594 / EY / NEI NIH HHS / United States
N01-HC-95163 / HC / NHLBI NIH HHS / United States
ZIA EY000426-13 / / Intramural NIH HHS / United States
HHSN268201100009C / / PHS HHS / United States
ZIA EY000403-14 / / Intramural NIH HHS / United States
ZIA EY000426-08 / / Intramural NIH HHS / United States
N01-HC-95159 / HC / NHLBI NIH HHS / United States
N01-HC-95165 / HC / NHLBI NIH HHS / United States
ZIA EY000403-11 / / Intramural NIH HHS / United States
Z01 EY000426-04 / / Intramural NIH HHS / United States
HHSN268201100010C / / PHS HHS / United States
ZIA EY000426-11 / / Intramural NIH HHS / United States
ZIA EY000403-10 / / Intramural NIH HHS / United States
HHSN268201100008C / / PHS HHS / United States
HHSN268201100012C / / PHS HHS / United States
ZIA EY000403-09 / / Intramural NIH HHS / United States
N01-HC-95164 / HC / NHLBI NIH HHS / United States
Z01 EY000403-06 / / Intramural NIH HHS / United States
ZIA EY000403-08 / / Intramural NIH HHS / United States
N01-HC-95160 / HC / NHLBI NIH HHS / United States
Z01 EY000403-07 / / Intramural NIH HHS / United States
HHSN268201100007C / / PHS HHS / United States
ZIAEY000403 / / PHS HHS / United States
ZIA EY000426-09 / / Intramural NIH HHS / United States
ZIA EY000426-07 / / Intramural NIH HHS / United States
ZIA EY000426-12 / / Intramural NIH HHS / United States
HHSN268201100011C / / PHS HHS / United States
N01-HC-95161 / HC / NHLBI NIH HHS / United States
ZIA EY000426-06 / / Intramural NIH HHS / United States
HHSN268201100006C / / PHS HHS / United States
ZIA EY000403-15 / / Intramural NIH HHS / United States
ZIA EY000403-12 / / Intramural NIH HHS / United States
EY-06594 / EY / NEI NIH HHS / United States