Pulse lineResearch With Heart Logo

Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association.

TitleOxidative Stress and IgG Antibody Modify Periodontitis-CRP Association.
Publication TypeJournal Article
Year of Publication2015
AuthorsSinger RE, Moss K, Kim SJ, Beck JD
Secondary AuthorsOffenbacher S
JournalJ Dent Res
Volume94
Issue12
Pagination1698-705
Date Published2015 Dec
ISSN1544-0591
KeywordsBiofilms, C-Reactive Protein, Dinoprost, Female, Humans, Immunoglobulin G, Male, Middle Aged, Mouth, Oxidative Stress, Periodontitis, Prospective Studies
Abstract

In a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum IgG antibodies to oral bacteria. The association between increased serum IgG with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. Other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic C-reactive protein (CRP) response. These observations led us to hypothesize that the reported relationship of periodontitis to elevated serum CRP, a systemic inflammatory marker, may be modified by oxidative stress and that the levels of serum antibodies to oral bacteria might be an intermediary explanatory variable linking the association of systemic oxidative stress, periodontal disease, and levels of CRP. This hypothesis was explored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using serum levels of CRP, serum IgG levels to 16 oral organisms, serum levels of 8-isoprostane, and periodontal status. The findings indicate periodontitis is associated with high CRP in the presence of elevated oxidative stress that serves to suppress the IgG response. Only within the highest 8-isoprostane quartile was periodontitis (pocket depth) associated with increased serum CRP levels (P = 0.0003). Increased serum IgG antibody levels to oral bacteria were associated with lowered serum CRP levels. Thus, systemic oxidative stress, which has been demonstrated to be associated with increased levels of CRP in other studies, appears to be associated with the suppression of bacterial-specific IgG levels, which in the presence of periodontal disease can result in an enhanced systemic CRP response. Conversely, individuals with increased serum IgG antibodies to plaque bacteria exhibit lowered serum CRP levels. These 2 factors, oxidative stress and the serum IgG response, appear to function in opposing directions to modify serum levels of CRP and the association with periodontitis.

DOI10.1177/0022034515602693
Alternate JournalJ Dent Res
PubMed ID26318589
PubMed Central IDPMC4681476
Grant ListN01HC55020 / HL / NHLBI NIH HHS / United States
R01 DE011551 / DE / NIDCR NIH HHS / United States
T90 DE021986 / DE / NIDCR NIH HHS / United States
R01-DE-11551 / DE / NIDCR NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01HC55022 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States