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Prospective study of plasma D-dimer and incident venous thromboembolism: The Atherosclerosis Risk in Communities (ARIC) Study.

TitleProspective study of plasma D-dimer and incident venous thromboembolism: The Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2015
AuthorsFolsom AR, Alonso A, George KM, Roetker NS, Tang W
Secondary AuthorsCushman M
JournalThromb Res
Volume136
Issue4
Pagination781-5
Date Published2015 Oct
ISSN1879-2472
KeywordsFemale, Fibrin Fibrinogen Degradation Products, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk Factors, Venous Thromboembolism
Abstract

INTRODUCTION: Plasma D-dimer is a useful clinical test for acute venous thromboembolism (VTE), and concentrations remain higher in VTE patients after treatment than in controls. Yet, evidence is limited on whether higher basal D-dimer concentrations in the general population are associated with greater risk of first VTE.

OBJECTIVE: To assess the prospective association between D-dimer and incident VTE over a long follow-up.

METHODS: We measured plasma D-dimer in 12,097 participants, initially free of VTE, in the Atherosclerosis Risk in Communities Study. Over a median follow-up of 17years, we identified 521 VTEs. We calculated hazard ratios of VTE using proportional hazards regression.

RESULTS: The age, race, and sex adjusted hazard ratios of VTE across quintiles of D-dimer were 1, 1.5, 1.8, 2.1, and 3.2 (p for trend

CONCLUSIONS: A higher basal level of plasma D-dimer in the general population, presumably reflecting a predisposition to thrombosis, is a strong, long-term risk factor for a first VTE.

DOI10.1016/j.thromres.2015.08.013
Alternate JournalThromb Res
PubMed ID26337932
PubMed Central IDPMC4577468
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
R01-HL059367 / HL / NHLBI NIH HHS / United States