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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

TitleA comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
Publication TypeJournal Article
Year of Publication2015
AuthorsNikpay M, Goel A, Won H-H, et al.
Secondary AuthorsFarrall M
JournalNat Genet
Volume47
Issue10
Pagination1121-1130
Date Published2015 Oct
ISSN1546-1718
KeywordsCoronary Artery Disease, Genome, Human, Genome-Wide Association Study, Humans, Phenotype
Abstract

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005

DOI10.1038/ng.3396
Alternate JournalNat Genet
PubMed ID26343387
PubMed Central IDPMC4589895
Grant ListRG/08/014/24067 / / British Heart Foundation / United Kingdom
R01 HL127564 / HL / NHLBI NIH HHS / United States
MR/L003120/1 / / Medical Research Council / United Kingdom
RE/13/1/30181 / / British Heart Foundation / United Kingdom
R33 HL120757 / HL / NHLBI NIH HHS / United States
UM1 CA182913 / CA / NCI NIH HHS / United States
R01 DK089256 / DK / NIDDK NIH HHS / United States
FS/14/55/30806 / / British Heart Foundation / United Kingdom
RG/14/5/30893 / / British Heart Foundation / United Kingdom
R01 HL117078 / HL / NHLBI NIH HHS / United States
MR/L01629X/1 / / Medical Research Council / United Kingdom