|Title||Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Schneider ALC, Jonassaint C, Sharrett ARichey, Mosley TH, Astor BC, Selvin E, Coresh JJ|
|Secondary Authors||Gottesman RF|
|Journal||J Gerontol A Biol Sci Med Sci|
|Date Published||2016 06|
|Keywords||Anemia, Cognition, Cross-Sectional Studies, Dementia, Female, Hemoglobins, Humans, Male, Middle Aged, Neuropsychological Tests, Prevalence, Prospective Studies, Risk Factors, United States|
BACKGROUND: Our objective was to characterize the relationship of low and high hemoglobin concentrations and normocytic, microcytic, and macrocytic anemia with cross-sectional cognition and change in cognition over a median of 6 years.
METHODS: Cross-sectional and prospective analyses of 13,133 participants (mean age 57 years, 56% women, 24% black, 10% anemia) in the Atherosclerosis Risk in Communities (ARIC) study (baseline 1990-1992) were carried out. Anemia was defined as hemoglobin concentrations lower than 13g/dl for men and lower than 12g/dl for women and was subclassified as normocytic (mean corpuscular volume [MCV] 80-100 fL), microcytic (MCV 100 fL). Cognition was assessed by delayed word recall test (DWRT), digit symbol substitution test (DSST), word fluency test (WFT), and global Z-score at Visit 2 (1990-1992) and Visit 4 (1996-1998). Adjusted linear regression models and splines were used.
RESULTS: Cross-sectionally, anemia overall was associated with lower cognitive test scores on DSST and global Z-score among men and women (all p .05).
CONCLUSIONS: There was a cross-sectional, but not prospective, nonlinear association between hemoglobin concentrations and cognitive function, although only associations of low levels of hemoglobin (anemia) were statistically significant. Subtypes of anemia had similar magnitudes of associations with cognition.
|Alternate Journal||J Gerontol A Biol Sci Med Sci|
|PubMed Central ID||PMC4888383|
|Grant List||HHSN268201100008C / HL / NHLBI NIH HHS / United States |
U01 HL096812 / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States