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Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study.

TitleHemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study.
Publication TypeJournal Article
Year of Publication2016
AuthorsSchneider ALC, Jonassaint C, Sharrett ARichey, Mosley TH, Astor BC, Selvin E, Coresh JJ
Secondary AuthorsGottesman RF
JournalJ Gerontol A Biol Sci Med Sci
Volume71
Issue6
Pagination772-9
Date Published2016 06
ISSN1758-535X
KeywordsAnemia, Cognition, Cross-Sectional Studies, Dementia, Female, Hemoglobins, Humans, Male, Middle Aged, Neuropsychological Tests, Prevalence, Prospective Studies, Risk Factors, United States
Abstract

BACKGROUND: Our objective was to characterize the relationship of low and high hemoglobin concentrations and normocytic, microcytic, and macrocytic anemia with cross-sectional cognition and change in cognition over a median of 6 years.

METHODS: Cross-sectional and prospective analyses of 13,133 participants (mean age 57 years, 56% women, 24% black, 10% anemia) in the Atherosclerosis Risk in Communities (ARIC) study (baseline 1990-1992) were carried out. Anemia was defined as hemoglobin concentrations lower than 13g/dl for men and lower than 12g/dl for women and was subclassified as normocytic (mean corpuscular volume [MCV] 80-100 fL), microcytic (MCV 100 fL). Cognition was assessed by delayed word recall test (DWRT), digit symbol substitution test (DSST), word fluency test (WFT), and global Z-score at Visit 2 (1990-1992) and Visit 4 (1996-1998). Adjusted linear regression models and splines were used.

RESULTS: Cross-sectionally, anemia overall was associated with lower cognitive test scores on DSST and global Z-score among men and women (all p .05).

CONCLUSIONS: There was a cross-sectional, but not prospective, nonlinear association between hemoglobin concentrations and cognitive function, although only associations of low levels of hemoglobin (anemia) were statistically significant. Subtypes of anemia had similar magnitudes of associations with cognition.

DOI10.1093/gerona/glv158
Alternate JournalJ Gerontol A Biol Sci Med Sci
PubMed ID26363510
PubMed Central IDPMC4888383
Grant ListHHSN268201100008C / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
T32 HL007024 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States