|Title||Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Butler KR, Penman AD, Minor DS|
|Secondary Authors||Mosley TH|
|Date Published||2015 Dec|
|Keywords||Adult, African Americans, Age Factors, Aging, Blood Pressure, Diabetes Mellitus, European Continental Ancestry Group, Female, Humans, Male, Middle Aged, Obesity, Risk Factors, Sex Factors|
INTRODUCTION: The aim of this study was to examine the effect of vascular and lifestyle risk factors on the annual rate of change in pulse pressure (PP) in a biracial, middle-aged cohort.
METHODS AND RESULTS: The study population, drawn from the Atherosclerosis Risk in Communities (ARIC) cohort, included 10, 071 participants, aged 45-64 years at baseline, with a complete set of SBP and DBP readings at each of four visits 3 years apart. The average annual increase in PP was 1.23 mmHg [standard error (SE 0.01], after adjusting for baseline age differences. Compared with white men, African-American women had the highest rate of annual increase in PP (0.41 (SE 0.05) mmHg/year greater) followed by white women [0.23 (SE 0.03) mmHg/year greater] and African-American men [0.19 (SE 0.06) mmHg/year greater].
CONCLUSION: There were significant differences in both average baseline PP and average annual rate of change in PP between men and women and African-Americans and whites. Diabetes and obesity had the strongest effect on the absolute value of baseline PP and the annual rate of change in PP.
|Alternate Journal||J Hypertens|
|Grant List||N01-HC-55015 / HC / NHLBI NIH HHS / United States |
N01-HC-55016 / HC / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01-HC-55019 / HC / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
N01-HC-55022 / HC / NHLBI NIH HHS / United States