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Lack of association of plasma factor XI with incident stroke and coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study.

TitleLack of association of plasma factor XI with incident stroke and coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2015
AuthorsFolsom AR, George KM
Secondary AuthorsAppiah D
JournalAtherosclerosis
Volume243
Issue1
Pagination181-5
Date Published2015 Nov
ISSN1879-1484
KeywordsAged, Atherosclerosis, Coronary Disease, Factor XI, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Stroke
Abstract

BACKGROUND AND AIMS: An elevated plasma concentration of intrinsic coagulation factor XI is a risk factor for venous thromboembolism, but its role in the etiology of atherothrombotic outcomes is uncertain. We examined the association of factor XI with incident stroke and coronary heart disease in the prospective Atherosclerosis Risk in Communities (ARIC) Study.

METHODS: We measured factor XI on plasma samples collected in 1993-1995 from middle-aged adults (n = 11,439), who were followed through 2012 for incident cardiovascular events.

RESULTS: Over a median of 18 years of follow-up (max = 20 years), 722 participants had incident stroke events (631 ischemic and 91 hemorrhagic) and 1776 had incident coronary events. Although there were weak positive associations between factor XI and total, ischemic, cardioembolic, and nonlacunar stroke, when adjusted for demographics, further adjustment for other stroke risk factors eliminated the associations. Similarly, there was no independent association of factor XI with incident coronary heart disease events.

CONCLUSION: A higher basal factor XI concentration in the general population was not a risk marker for stroke or coronary heart disease.

DOI10.1016/j.atherosclerosis.2015.09.015
Alternate JournalAtherosclerosis
PubMed ID26386215
PubMed Central IDPMC4620543
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
268201100011C / / PHS HHS / United States
268201100005C / / PHS HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
268201100007C / / PHS HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
R01 HL059367 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
268201100012C / / PHS HHS / United States
268201100008C / / PHS HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
268201100009C / / PHS HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
268201100006C / / PHS HHS / United States
268201100010C / / PHS HHS / United States