|Title||Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||B Windham G, Griswold ME, Lirette S, Kucharska-Newton AMaria, Foraker RE, Rosamond WD, Coresh JJ, Kritchevsky S|
|Secondary Authors||Mosley TH|
|Journal||J Gerontol A Biol Sci Med Sci|
|Date Published||2017 01|
|Keywords||Activities of Daily Living, Age Factors, Aged, Atherosclerosis, Female, Health Status, Humans, Hypertension, Male, Middle Aged, Proportional Hazards Models, Risk Factors|
BACKGROUND: Impaired functional status attenuates the relationship of systolic blood pressure (SBP) with mortality in older adults but has not been studied in middle-aged populations.
METHOD: Among 10,264 stroke-free Atherosclerosis Risk in Communities participants (mean age 62.8 [5.7] years; 6,349 [62%] younger [
RESULTS: Mean follow-up was 12.9 years with 2,863 (28%) deaths. Among younger participants, 3,017 (48%) had IF; 2,279 of 3,915 (58%) older participants had IF. Prehypertension (hazard ratio [HR] = 1.48 [1.03, 2.15] p = .04) and hypertension (HR = 1.97 [1.29, 3.03] p = .002) were associated with mortality in younger GF and older (≥65 years) GF participants (prehypertension HR = 1.21 [1.06, 1.37] p = .005; hypertension HR = 1.47 [1.36, 1.59] p
CONCLUSIONS: Compared with younger and well-functioning persons, the additional contribution of blood pressure to mortality is much lower with older age and impaired function, particularly if both are present. Functional status and age could potentially inform optimal blood pressure targets.
|Alternate Journal||J Gerontol A Biol Sci Med Sci|
|PubMed Central ID||PMC5155654|