Pulse lineResearch With Heart Logo

Effects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study.

TitleEffects of Age and Functional Status on the Relationship of Systolic Blood Pressure With Mortality in Mid and Late Life: The ARIC Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsB Windham G, Griswold ME, Lirette S, Kucharska-Newton AMaria, Foraker RE, Rosamond WD, Coresh JJ, Kritchevsky S
Secondary AuthorsMosley TH
JournalJ Gerontol A Biol Sci Med Sci
Volume72
Issue1
Pagination89-94
Date Published2017 01
ISSN1758-535X
KeywordsActivities of Daily Living, Age Factors, Aged, Atherosclerosis, Female, Health Status, Humans, Hypertension, Male, Middle Aged, Proportional Hazards Models, Risk Factors
Abstract

BACKGROUND: Impaired functional status attenuates the relationship of systolic blood pressure (SBP) with mortality in older adults but has not been studied in middle-aged populations.

METHOD: Among 10,264 stroke-free Atherosclerosis Risk in Communities participants (mean age 62.8 [5.7] years; 6,349 [62%] younger [

RESULTS: Mean follow-up was 12.9 years with 2,863 (28%) deaths. Among younger participants, 3,017 (48%) had IF; 2,279 of 3,915 (58%) older participants had IF. Prehypertension (hazard ratio [HR] = 1.48 [1.03, 2.15] p = .04) and hypertension (HR = 1.97 [1.29, 3.03] p = .002) were associated with mortality in younger GF and older (≥65 years) GF participants (prehypertension HR = 1.21 [1.06, 1.37] p = .005; hypertension HR = 1.47 [1.36, 1.59] p

CONCLUSIONS: Compared with younger and well-functioning persons, the additional contribution of blood pressure to mortality is much lower with older age and impaired function, particularly if both are present. Functional status and age could potentially inform optimal blood pressure targets.

DOI10.1093/gerona/glv162
Alternate JournalJ Gerontol A Biol Sci Med Sci
PubMed ID26409066
PubMed Central IDPMC5155654