|Title||Diabetes mellitus and venous thromboembolism: A systematic review and meta-analysis.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Bell EJ, Folsom AR, Lutsey PL, Selvin E, Zakai NA, Cushman M|
|Secondary Authors||Alonso A|
|Journal||Diabetes Res Clin Pract|
|Date Published||2016 Jan|
|Keywords||Diabetes Mellitus, Diabetic Angiopathies, Humans, Risk Factors, Venous Thromboembolism|
UNLABELLED: Diabetes mellitus (DM) may be a risk factor for venous thromboembolism (VTE) but results are inconsistent.
AIM: We conducted a systematic review and meta-analysis of epidemiologic studies to quantify the association between DM and VTE.
METHODS AND RESULTS: We included studies identified in PubMed, Web of Science, and CINAHL through 07/31/2014. We identified 19 studies that met our selection criteria. We pooled RRs using a random-effects model: the pooled RR for the association of DM with VTE was 1.10 (95% CI: 0.94-1.29). Between-study heterogeneity was explored with a forest plot, funnel plot, meta-regression, and a stratified analysis. Between-study heterogeneity was observed and not explained by study design, method of DM assessment, or degree of adjustment for confounding. Sensitivity analyses omitted one study at a time to assess the influence of any single study on the pooled estimate. These analyses indicated that one large study was highly influential; when this study was excluded, the pooled estimate increased and just reached statistical significance: 1.16 (95% CI: 1.01-1.34).
CONCLUSIONS: This meta-analysis suggests either no association or a modest positive one between DM and VTE in the general population. DM is unlikely to play a major role in VTE development.
|Alternate Journal||Diabetes Res Clin Pract|
|PubMed Central ID||PMC4752919|
|Grant List||K24 DK106414 / DK / NIDDK NIH HHS / United States |
R01 HL059367 / HL / NHLBI NIH HHS / United States
T32 HL007779 / HL / NHLBI NIH HHS / United States
T32HL007779 / HL / NHLBI NIH HHS / United States