Pulse lineResearch With Heart Logo

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

TitleNew loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Publication TypeJournal Article
Year of Publication2016
AuthorsLu Y, Day FR, Gustafsson S, et al.
Secondary AuthorsLoos RJF
JournalNat Commun
Volume7
Pagination10495
Date Published2016 Feb 01
ISSN2041-1723
KeywordsAdiposity, Animals, Drosophila melanogaster, Gene Expression Regulation, Gene Knockdown Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Diseases, Humans, Quantitative Trait Loci
Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P

DOI10.1038/ncomms10495
Alternate JournalNat Commun
PubMed ID26833246
PubMed Central IDPMC4740398
Grant ListR01 DK093757 / DK / NIDDK NIH HHS / United States
MC_U147574242 / / Medical Research Council / United Kingdom
/ / British Heart Foundation / United Kingdom
MR/K002414/1 / / Medical Research Council / United Kingdom
MC_UP_A100_1003 / / Medical Research Council / United Kingdom
R01 DK106236 / DK / NIDDK NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
P30 DK079637 / DK / NIDDK NIH HHS / United States
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
MR/J012165/1 / / Medical Research Council / United Kingdom
/ / Department of Health / United Kingdom
R01 DK075787 / DK / NIDDK NIH HHS / United States
R01 AR041398 / AR / NIAMS NIH HHS / United States
MC_UU_12015/1 / / Medical Research Council / United Kingdom
MC_U106179471 / / Medical Research Council / United Kingdom
K01 HL129892 / HL / NHLBI NIH HHS / United States
MC_UU_12015/2 / / Medical Research Council / United Kingdom
MR/J010642/1 / / Medical Research Council / United Kingdom
MC_UU_12011/3 / / Medical Research Council / United Kingdom
/ / Canadian Institutes of Health Research / Canada
P30 AG010161 / AG / NIA NIH HHS / United States
MC_U106179472 / / Medical Research Council / United Kingdom
IK2 CX000729 / CX / CSRD VA / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
MC_UU_12013/4 / / Medical Research Council / United Kingdom
MC_PC_U127561128 / / Medical Research Council / United Kingdom
U01 DK062370 / DK / NIDDK NIH HHS / United States
/ / Arthritis Research UK / United Kingdom
R01 DK089256 / DK / NIDDK NIH HHS / United States
K01 AR062655 / AR / NIAMS NIH HHS / United States
MR/K006584/1 / / Medical Research Council / United Kingdom
MR/K013351/1 / / Medical Research Council / United Kingdom
281641 / / European Research Council / International
P30 DK020572 / DK / NIDDK NIH HHS / United States
MC_UU_12015/5 / / Medical Research Council / United Kingdom
/ / Chief Scientist Office / United Kingdom
MC_UU_12011/4 / / Medical Research Council / United Kingdom
R01 HL117078 / HL / NHLBI NIH HHS / United States
MC_UP_A620_1016 / / Medical Research Council / United Kingdom
10589 / / Cancer Research UK / United Kingdom
/ / Wellcome Trust / United Kingdom
R01 AG027574 / AG / NIA NIH HHS / United States