| Title | New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Lu Y, Day FR, Gustafsson S, et al. |
| Secondary Authors | Loos RJF |
| Journal | Nat Commun |
| Volume | 7 |
| Pagination | 10495 |
| Date Published | 2016 Feb 01 |
| ISSN | 2041-1723 |
| Keywords | Adiposity, Animals, Drosophila melanogaster, Gene Expression Regulation, Gene Knockdown Techniques, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Diseases, Humans, Quantitative Trait Loci |
| Abstract | To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P |
| DOI | 10.1038/ncomms10495 |
| Alternate Journal | Nat Commun |
| PubMed ID | 26833246 |
| PubMed Central ID | PMC4740398 |
| Grant List | R01 DK093757 / DK / NIDDK NIH HHS / United States MC_U147574242 / / Medical Research Council / United Kingdom / / British Heart Foundation / United Kingdom MR/K002414/1 / / Medical Research Council / United Kingdom MC_UP_A100_1003 / / Medical Research Council / United Kingdom R01 DK106236 / DK / NIDDK NIH HHS / United States R01 DK072193 / DK / NIDDK NIH HHS / United States P30 DK079637 / DK / NIDDK NIH HHS / United States / / Biotechnology and Biological Sciences Research Council / United Kingdom MR/J012165/1 / / Medical Research Council / United Kingdom / / Department of Health / United Kingdom R01 DK075787 / DK / NIDDK NIH HHS / United States R01 AR041398 / AR / NIAMS NIH HHS / United States MC_UU_12015/1 / / Medical Research Council / United Kingdom MC_U106179471 / / Medical Research Council / United Kingdom K01 HL129892 / HL / NHLBI NIH HHS / United States MC_UU_12015/2 / / Medical Research Council / United Kingdom MR/J010642/1 / / Medical Research Council / United Kingdom MC_UU_12011/3 / / Medical Research Council / United Kingdom / / Canadian Institutes of Health Research / Canada P30 AG010161 / AG / NIA NIH HHS / United States MC_U106179472 / / Medical Research Council / United Kingdom IK2 CX000729 / CX / CSRD VA / United States P30 DK020541 / DK / NIDDK NIH HHS / United States MC_UU_12013/4 / / Medical Research Council / United Kingdom MC_PC_U127561128 / / Medical Research Council / United Kingdom U01 DK062370 / DK / NIDDK NIH HHS / United States / / Arthritis Research UK / United Kingdom R01 DK089256 / DK / NIDDK NIH HHS / United States K01 AR062655 / AR / NIAMS NIH HHS / United States MR/K006584/1 / / Medical Research Council / United Kingdom MR/K013351/1 / / Medical Research Council / United Kingdom 281641 / / European Research Council / International P30 DK020572 / DK / NIDDK NIH HHS / United States MC_UU_12015/5 / / Medical Research Council / United Kingdom / / Chief Scientist Office / United Kingdom MC_UU_12011/4 / / Medical Research Council / United Kingdom R01 HL117078 / HL / NHLBI NIH HHS / United States MC_UP_A620_1016 / / Medical Research Council / United Kingdom 10589 / / Cancer Research UK / United Kingdom / / Wellcome Trust / United Kingdom R01 AG027574 / AG / NIA NIH HHS / United States |