| Title | Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Verweij N, Mateo Leach I, Isaacs A, Arking DE, Bis JC, Pers TH, van den Berg ME, Lyytikäinen L-P, Barnett P, Wang X, Soliman EZ, van Duijn CM, Kähönen M, van Veldhuisen DJ, Kors JA, Raitakari OT, Silva CT, Lehtimäki T, Hillege HL, Hirschhorn JN, Boyer LA, van Gilst WH, Alonso A, Sotoodehnia N, Eijgelsheim M, de Boer RA, de Bakker PIW, Franke L |
| Secondary Authors | van der Harst P |
| Corporate Authors | LifeLines Cohort Study |
| Journal | Hum Mol Genet |
| Volume | 25 |
| Issue | 10 |
| Pagination | 2093-2103 |
| Date Published | 2016 05 15 |
| ISSN | 1460-2083 |
| Keywords | Adaptor Proteins, Signal Transducing, Arrhythmias, Cardiac, Basic Helix-Loop-Helix Transcription Factors, Brugada Syndrome, Cardiac Conduction System Disease, Death, Sudden, Cardiac, Electrocardiography, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Heart Conduction System, Humans, Male, NAV1.5 Voltage-Gated Sodium Channel, Polymorphism, Single Nucleotide, Repressor Proteins, Shab Potassium Channels, Shal Potassium Channels |
| Abstract | The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype-phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying the phenotypes, including genes with established roles in the cardiac repolarization phase (SCN5A/SCN10A, KCND3, KCNB1, NOS1AP and HEY2) and others with as yet undefined cardiac function. These associations may provide insights in the spatiotemporal contribution of genetic variation influencing cardiac repolarization and provide novel leads for future functional follow-up. |
| DOI | 10.1093/hmg/ddw058 |
| Alternate Journal | Hum Mol Genet |
| PubMed ID | 26962151 |
| PubMed Central ID | PMC5062578 |
| Grant List | R01 DK075787 / DK / NIDDK NIH HHS / United States R01 HL105756 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States |