Title | Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Rubin J, Matsushita K, Lazo M, Ballantyne CM, Nambi V, Hoogeveen RC, Sharrett ARichey, Blumenthal RS, Coresh JJ |
Secondary Authors | Selvin E |
Journal | Clin Biochem |
Volume | 49 |
Issue | 9 |
Pagination | 657-662 |
Date Published | 2016 Jun |
ISSN | 1873-2933 |
Keywords | Adult, Biomarkers, Cross-Sectional Studies, Female, Follow-Up Studies, Heart Diseases, Humans, Male, Middle Aged, Prognosis, Risk Assessment, Risk Factors, Troponin T, United States |
Abstract | OBJECTIVES: To study the relationship between cardiovascular risk factors and detectable cardiac troponin-T using a highly sensitive assay (hs-cTnT) among persons without a history of cardiovascular disease. DESIGN AND METHODS: We examined the cross-sectional associations between cardiovascular risk factors and hs-cTnT in 9593 participants (mean age 65.6 (SD, 5.6), 41% female, 22% black) free of cardiovascular disease in a community-based cohort, through the Atherosclerosis Risk in Communities (ARIC) Study. We used multivariable logistic regression to characterize the association between cardiovascular risk factors and detectable (≥3.0 to 13.9ng/L) and elevated (≥14.0ng/L) hs-cTnT. RESULTS: hs-cTnT was detectable in 59% and elevated in 7% of the study population. Among persons with ideal cardiovascular health, hs-cTnT was detectable in 44%. In models adjusting for significant determinants of hs-cTnT concentration, detectable hs-cTnT was more frequent among males, blacks and persons with diabetes and hypertension and less frequent among statin users, current smokers and drinkers. Other risk factors associated with detectable hs-cTnT were older age, lower kidney function and higher body mass index. These risk factors were associated with elevated hs-cTnT in a similar pattern. CONCLUSION: In a community-based sample without cardiovascular disease hs-cTnT is detectable in most adults, even among those with ideal cardiovascular health. Although most traditional cardiovascular risk factors were significant determinants of detectable and elevated hs-cTnT, the associations were particularly robust for sex, age, race, hypertension and diabetes. |
DOI | 10.1016/j.clinbiochem.2016.01.024 |
Alternate Journal | Clin Biochem |
PubMed ID | 26975902 |
PubMed Central ID | PMC4889514 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 DK089174 / DK / NIDDK NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States T32 HL007024 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States K24 DK106414 / DK / NIDDK NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |