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Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.

TitleSerum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.
Publication TypeJournal Article
Year of Publication2016
AuthorsShrestha S, Lutsey PL, Alonso A, Huang X, Mosley TH
Secondary AuthorsChen H
JournalMov Disord
Volume31
Issue7
Pagination972-8
Date Published2016 07
ISSN1531-8257
KeywordsAftercare, Aged, Female, Humans, Male, Middle Aged, Parkinson Disease, Risk, Vitamin D
Abstract

BACKGROUND: Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.

METHODS: Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association between serum 25-hydroxyvitamin D concentrations and PD risk, regardless of how serum 25-hydroxyvitamin D was modeled. Compared with participants with serum 25-hydroxyvitamin D

CONCLUSION: This prospective study lends no support to the hypothesis that vitamin D may reduce the risk of PD. Ā© 2016 International Parkinson and Movement Disorder Society.

DOI10.1002/mds.26573
Alternate JournalMov Disord
PubMed ID27090608
PubMed Central IDPMC4931952
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 HL103706 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 ES019672 / ES / NIEHS NIH HHS / United States
Z01 ES101986-03 / ImNIH / Intramural NIH HHS / United States
U01 NS082151 / NS / NINDS NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 NS060722 / NS / NINDS NIH HHS / United States
Z01 ES101986 / ImNIH / Intramural NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States