Pulse lineResearch With Heart Logo

Life-course blood pressure in relation to brain volumes.

TitleLife-course blood pressure in relation to brain volumes.
Publication TypeJournal Article
Year of Publication2016
AuthorsPower MC, Schneider ALC, Wruck L, Griswold M, Coker LH, Alonso A, Jack CR, Knopman D, Mosley TH
Secondary AuthorsGottesman RF
JournalAlzheimers Dement
Volume12
Issue8
Pagination890-9
Date Published2016 08
ISSN1552-5279
KeywordsAge Factors, Aged, Aged, 80 and over, Aging, Atherosclerosis, Blood Pressure, Brain, Female, Humans, Hypertension, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Residence Characteristics, United States
Abstract

INTRODUCTION: The impact of blood pressure on brain volumes may be time-dependent or pattern-dependent.

METHODS: Of 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (∼24 or ∼15 years prior and concurrent with neuroimaging) with late life brain volumes.

RESULTS: Higher diastolic blood pressure ∼24 years prior, higher systolic and pulse pressure ∼15 years prior, and consistently elevated or rising systolic blood pressure from ∼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension ∼15 years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus: -0.27 standard units, 95% CI: -0.51, -0.03).

DISCUSSION: Hypertension 15 to 24 years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental.

DOI10.1016/j.jalz.2016.03.012
Alternate JournalAlzheimers Dement
PubMed ID27139841
PubMed Central IDPMC4980244
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
R01 AG011378 / AG / NIA NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
K24 AG052573 / AG / NIA NIH HHS / United States
U01 AG006786 / AG / NIA NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 AG041851 / AG / NIA NIH HHS / United States
T32 AG027668 / AG / NIA NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
R01 AG037551 / AG / NIA NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
R01 AG043392 / AG / NIA NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States