Title | Life-course blood pressure in relation to brain volumes. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Power MC, Schneider ALC, Wruck L, Griswold M, Coker LH, Alonso A, Jack CR, Knopman D, Mosley TH |
Secondary Authors | Gottesman RF |
Journal | Alzheimers Dement |
Volume | 12 |
Issue | 8 |
Pagination | 890-9 |
Date Published | 2016 08 |
ISSN | 1552-5279 |
Keywords | Age Factors, Aged, Aged, 80 and over, Aging, Atherosclerosis, Blood Pressure, Brain, Female, Humans, Hypertension, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Residence Characteristics, United States |
Abstract | INTRODUCTION: The impact of blood pressure on brain volumes may be time-dependent or pattern-dependent. METHODS: Of 1678 participants from the Atherosclerosis Risk in Communities Neurocognitive Study, we quantified the association between measures and patterns of blood pressure over three time points (∼24 or ∼15 years prior and concurrent with neuroimaging) with late life brain volumes. RESULTS: Higher diastolic blood pressure ∼24 years prior, higher systolic and pulse pressure ∼15 years prior, and consistently elevated or rising systolic blood pressure from ∼15 years prior to concurrent with neuroimaging, but not blood pressures measured concurrent with neuroimaging, were associated with smaller volumes. The pattern of hypertension ∼15 years prior and hypotension concurrent with neuroimaging was associated with smaller volumes in regions preferentially affected by Alzheimer's disease (e.g., hippocampus: -0.27 standard units, 95% CI: -0.51, -0.03). DISCUSSION: Hypertension 15 to 24 years prior is relevant to current brain volumes. Hypertension followed by hypotension appears particularly detrimental. |
DOI | 10.1016/j.jalz.2016.03.012 |
Alternate Journal | Alzheimers Dement |
PubMed ID | 27139841 |
PubMed Central ID | PMC4980244 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States U01 HL096812 / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States U01 HL096902 / HL / NHLBI NIH HHS / United States R01 AG011378 / AG / NIA NIH HHS / United States U01 HL096814 / HL / NHLBI NIH HHS / United States K24 AG052573 / AG / NIA NIH HHS / United States U01 AG006786 / AG / NIA NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States R01 AG041851 / AG / NIA NIH HHS / United States T32 AG027668 / AG / NIA NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States U01 HL096917 / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States R01 AG037551 / AG / NIA NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States R01 AG043392 / AG / NIA NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States R01 HL070825 / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States U01 HL096899 / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |