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Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.

TitleEvidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Publication TypeJournal Article
Year of Publication2017
AuthorsHinney A, Kesselmeier M, Jall S, Volckmar A-L, Föcker M, Antel J, Heid IM, Winkler TW, Grant SFA, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, V Perica B, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD
Secondary AuthorsHebebrand J
Corporate AuthorsGCAN, WTCCC3, GIANT, EGG, Price Foundation Collaborative Group, Children’s Hospital of Philadelphia/Price Foundation
JournalMol Psychiatry
Volume22
Issue2
Pagination192-201
Date Published2017 02
ISSN1476-5578
KeywordsAlleles, Anorexia Nervosa, Body Mass Index, Body Weight, Databases, Genetic, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Obesity, Polymorphism, Single Nucleotide, Risk Factors
Abstract

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values

DOI10.1038/mp.2016.71
Alternate JournalMol Psychiatry
PubMed ID27184124
PubMed Central IDPMC5114162
Grant ListK01 MH109782 / MH / NIMH NIH HHS / United States
K01 MH106675 / MH / NIMH NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
K01 MH100435 / MH / NIMH NIH HHS / United States
R01 HD056465 / HD / NICHD NIH HHS / United States
T32 MH076694 / MH / NIMH NIH HHS / United States
MC_UU_12013/4 / / Medical Research Council / United Kingdom
U54 HD086984 / HD / NICHD NIH HHS / United States
MR/K013351/1 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom