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The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE.

TitleThe ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE.
Publication TypeJournal Article
Year of Publication2016
AuthorsGottesman RF, Schneider ALC, Zhou Y, Chen X, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett ARichey, Wagenknecht LE, Wong DF
Secondary AuthorsMosley TH
Date Published2016 Aug 02
KeywordsAfrican Americans, Aged, Aged, 80 and over, Aging, Alleles, Amyloid, Aniline Compounds, Apolipoprotein E4, Brain, Cognition, Continental Population Groups, Educational Status, Ethylene Glycols, Female, Functional Neuroimaging, Humans, Male, Positron-Emission Tomography, Sex Characteristics, White Matter

OBJECTIVE: To evaluate differences in amyloid deposition in a community-based cohort without dementia by age, sex, race, education, and APOE ε4 allele status.

METHODS: Recruited from the longitudinal Atherosclerosis Risk in Communities study, 329 participants without dementia, ages 67-88 years, were imaged using florbetapir PET at 3 US community sites (Washington County, Maryland; Forsyth County, North Carolina; and Jackson, Mississippi). Standardized uptake value ratios (SUVRs) were calculated; global cortical SUVR >1.2 was evaluated as the primary outcome. Age, race, sex, education level, and number of APOE ε4 alleles were evaluated in multivariable models including vascular risk factors, brain white matter hyperintensity and total intracranial volume, and cognitive status.

RESULTS: A total of 141 of the participants (43%) were black. In multivariable models, odds of elevated SUVR was increased in participants with increasing age (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.01-2.65 per 10 years of age) and black race (OR 2.08, 95% CI 1.23-3.51) but did not differ by educational level. Each ε4 allele was associated with increased odds of elevated SUVR (OR 2.65, 95% CI 1.61-4.39).

CONCLUSIONS: In this community-based cohort without dementia, florbetapir uptake is associated with older age and APOE genotype. Black race was associated with higher SUVR, after adjusting for demographics, vascular risk factors, cognitive status, white matter hyperintensity volume, and APOE genotype, with effect sizes nearing those seen for APOE ε4. Replication of these findings is needed in other cohorts, and reasons for and consequences of these observed differences by race warrant further study.

Alternate JournalNeurology
PubMed ID27371485
PubMed Central IDPMC4970663
Grant ListU01 HL096812 / HL / NHLBI NIH HHS / United States
P50 AG005146 / AG / NIA NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
R01 AG040282 / AG / NIA NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States