Pulse lineResearch With Heart Logo

Association of Age at Menopause With Incident Heart Failure: A Prospective Cohort Study and Meta-Analysis.

TitleAssociation of Age at Menopause With Incident Heart Failure: A Prospective Cohort Study and Meta-Analysis.
Publication TypeJournal Article
Year of Publication2016
AuthorsAppiah D, Schreiner PJ, Demerath EW, Loehr LR, Chang PP
Secondary AuthorsFolsom AR
JournalJ Am Heart Assoc
Volume5
Issue8
Date Published2016 07 28
ISSN2047-9980
KeywordsAdult, Age Factors, Cardiovascular Diseases, Female, Heart Failure, Humans, Incidence, Kaplan-Meier Estimate, Menopause, Middle Aged, Prospective Studies, United States
Abstract

BACKGROUND: Early age (

METHODS AND RESULTS: In ARIC, data were obtained from 5629 postmenopausal women (mean age 56 years, 26% with bilateral oophorectomy) without HF. During a median follow-up of 21.4 years, 965 incident HF events occurred. In a Cox regression model adjusted for reproductive health and HF risk factors, the hazard ratios for incident HF across categories of age at menopause (

CONCLUSIONS: These results provided evidence that early age at menopause is associated with a modestly greater risk of HF. Identification of women with early menopause offers a window of opportunity to implement interventions that will improve overall cardiovascular health during the postmenopausal years.

DOI10.1161/JAHA.116.003769
Alternate JournalJ Am Heart Assoc
PubMed ID27468929
PubMed Central IDPMC5015298
Grant ListT32 HL007779 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States