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Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort.

TitleOperationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort.
Publication TypeJournal Article
Year of Publication2017
AuthorsKucharska-Newton AMaria, Palta P, Burgard S, Griswold ME, Lund JL, Capistrant BD, Kritchevsky SB, Bandeen-Roche K
Secondary AuthorsB Windham G
JournalJ Gerontol A Biol Sci Med Sci
Volume72
Issue3
Pagination382-388
Date Published2017 03 01
ISSN1758-535X
KeywordsAged, Aged, 80 and over, Atherosclerosis, Cohort Studies, Female, Frail Elderly, Geriatric Assessment, Humans, Male, Phenotype, Risk Assessment
Abstract

Background: Factors that may contribute to the development of frailty in late life have not been widely investigated. The Atherosclerosis Risk in Communities (ARIC) Study cohort presents an opportunity to examine relationships of midlife risk factors with frailty in late life. However, we first present findings on the validation of an established frailty phenotype in this predominantly biracial population of older adults.

Methods: Among 6,080 participants, we defined frailty based upon the Cardiovascular Health Study (CHS) criteria incorporating measures of weight loss, exhaustion, slow walking speed, low physical activity, and low grip strength. Criterion and predictive validity of the frailty phenotype were estimated from associations between frailty status and participants' physical and mental health status, physiologic markers, and incident clinical outcomes.

Results: A total of 393 (6.5%) participants were classified as frail and 50.4% pre-frail, similar to CHS (6.9% frail, 46.6% pre-frail). In age-adjusted analyses, frailty was concurrently associated with depressive symptoms, low self-rated health, low medication adherence, and clinical biomarker levels (ie, cholesterol, hemoglobin A1c, white blood cell count, C-reactive protein, and hemoglobin). During 1-year follow-up, frailty was associated with falls, low physical ability, fatigue, and mortality.

Conclusions: These findings support the validity of the CHS frailty phenotype in the ARIC Study cohort. Future studies in ARIC may elucidate early-life exposures that contribute to late-life frailty.

DOI10.1093/gerona/glw144
Alternate JournalJ Gerontol A Biol Sci Med Sci
PubMed ID27470301
PubMed Central IDPMC6075198
Grant ListHHSN268201100008C / HL / NHLBI NIH HHS / United States
U01 HL096812 / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
U01 HL096917 / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
P30 AG021334 / AG / NIA NIH HHS / United States
T32 HL007055 / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States