Pulse lineResearch With Heart Logo

Association of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities).

TitleAssociation of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities).
Publication TypeJournal Article
Year of Publication2016
AuthorsBello NA, Cheng S, Claggett B, Shah AM, Ndumele CE, Roca GQuerejeta, Santos ABS, Gupta D, Vardeny O, Aguilar D, Folsom AR, Butler KR, Kitzman DW, Coresh JJ
Secondary AuthorsSolomon SD
JournalCirc Heart Fail
Volume9
Issue8
Date Published2016 08
ISSN1941-3297
KeywordsAdiposity, African Americans, Aged, Aged, 80 and over, Atherosclerosis, Body Mass Index, Body Weight, Cross-Sectional Studies, Echocardiography, Doppler, European Continental Ancestry Group, Female, Humans, Hypertrophy, Left Ventricular, Male, Obesity, Prospective Studies, Risk Factors, United States, Ventricular Dysfunction, Left, Ventricular Dysfunction, Right, Ventricular Function, Left, Ventricular Function, Right, Ventricular Remodeling, Waist Circumference
Abstract

BACKGROUND: Obesity increases cardiovascular risk. However, the extent to which various measures of body composition are associated with abnormalities in cardiac structure and function, independent of comorbidities commonly affecting obese individuals, is not clear. This study sought to examine the relationship between body mass index, waist circumference, and percent body fat with conventional and advanced measures of cardiac structure and function.

METHODS AND RESULTS: We studied 4343 participants of the ARIC study (Atherosclerosis Risk in Communities) who were aged 69 to 82 years, free of coronary heart disease and heart failure, and underwent comprehensive echocardiography. Increasing body mass index, waist circumference, and body fat were associated with greater left ventricular (LV) mass and left atrial volume indexed to height(2.7) in both men and women (P

CONCLUSIONS: In a large, biracial cohort of older adults free of clinically overt coronary heart disease or heart failure, obesity was associated with subclinical abnormalities in cardiac structure in both men and women and with adverse LV remodeling and impaired LV systolic function in women. These data highlight the association of obesity and subclinical abnormalities of cardiac structure and function, particularly in women.

DOI10.1161/CIRCHEARTFAILURE.115.002978
Alternate JournalCirc Heart Fail
PubMed ID27512104
PubMed Central IDPMC5218510
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
K08 HL116792 / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
R00 HL107642 / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
T32 HL007374 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States