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Physical Activity, Parental History of Premature Coronary Heart Disease, and Incident Atherosclerotic Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study.

TitlePhysical Activity, Parental History of Premature Coronary Heart Disease, and Incident Atherosclerotic Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2016
AuthorsFlorido R, Zhao D, Ndumele CE, Lutsey PL, McEvoy JW, B Windham G, Pankow JS, Guallar E
Secondary AuthorsMichos ED
JournalJ Am Heart Assoc
Volume5
Issue9
Date Published2016 08 30
ISSN2047-9980
KeywordsAmerican Heart Association, Atherosclerosis, Cardiovascular Diseases, Coronary Disease, Exercise, Female, Follow-Up Studies, Guideline Adherence, Humans, Incidence, Male, Medical History Taking, Middle Aged, Multivariate Analysis, Myocardial Infarction, Proportional Hazards Models, Risk Factors, Stroke, United States
Abstract

BACKGROUND: The effects of some atherosclerotic cardiovascular disease (ASCVD) risk factors vary according to whether an individual has a family history (FHx) of premature coronary heart disease (CHD). Physical activity (PA) is associated with reduced risk of ASCVD, but whether this association varies by FHx status is not well established.

METHODS AND RESULTS: We evaluated 9996 participants free of ASCVD at baseline. FHx of premature CHD was defined as CHD occurring in a father before age 55 or mother before age 60. PA, assessed by a Baecke questionnaire, was converted into minutes/week of moderate or vigorous exercise and categorized per American Heart Association guidelines as recommended, intermediate, or poor. Incident ASCVD was defined as incident myocardial infarction, fatal CHD, or stroke. Multivariable-adjusted Cox hazard models were used. The mean age was 54±6 years, 56% were women, and 21% of black race. Participants with and without a FHx of premature CHD reported similar levels of PA at baseline (423 versus 409 metabolic equivalents of task×min/week, respectively, P=0.852), and ≈40% of both groups met American Heart Association recommended PA levels. Over a mean follow-up of 20.9 years, there were 1723 incident ASCVD events. Compared to those with poor PA adherence to American Heart Association guidelines, participants who reported PA at recommended levels had significantly lower risk of incident ASCVD after adjustment for demographics and lifestyle factors (hazard ratio 0.84, 95% CI 0.74-0.94), but this association was not modified by FHx status (P-interaction=0.680).

CONCLUSIONS: PA was associated with a reduced risk of ASCVD among individuals with and without a FHx of premature CHD.

DOI10.1161/JAHA.116.003505
Alternate JournalJ Am Heart Assoc
PubMed ID27577582
PubMed Central IDPMC5079018
Grant ListHHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States