Title | Smoking and Cardiac Structure and Function in the Elderly: The ARIC Study (Atherosclerosis Risk in Communities). |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Nadruz W, Claggett B, Gonçalves A, Querejeta-Roca G, Fernandes-Silva MM, Shah AM, Cheng S, Tanaka H, Heiss G, Kitzman DW |
Secondary Authors | Solomon SD |
Journal | Circ Cardiovasc Imaging |
Volume | 9 |
Issue | 9 |
Pagination | e004950 |
Date Published | 2016 Sep |
ISSN | 1942-0080 |
Keywords | Age Factors, Aged, Aged, 80 and over, Aging, Atherosclerosis, Chi-Square Distribution, Cross-Sectional Studies, Diastole, Echocardiography, Female, Humans, Hypertrophy, Left Ventricular, Linear Models, Male, Middle Aged, Multivariate Analysis, Prevalence, Prospective Studies, Risk Factors, Smoking, Time Factors, United States, Ventricular Function, Left, Ventricular Remodeling |
Abstract | BACKGROUND: Cigarette smoking has been associated with higher risk of incident heart failure independent of coronary artery disease, but the impact of tobacco use on cardiac structure and function in the general population is uncertain. This study evaluated the relationship between smoking and echocardiographic measures in a large elderly cohort. METHODS AND RESULTS: We studied 4580 participants free of overt coronary artery disease, heart failure, and significant valvular disease from the fifth visit of the ARIC study (Atherosclerosis Risk in Communities) who underwent transthoracic echocardiography. Participants were classified into 3 categories based on self-reported smoking habits: never (43.2%), former (50.5%), and current smokers (6.3%). Pack-years and years of smoking were also estimated. Compared with never smokers, current smokers had greater left ventricular (LV) mass index (80.4±1.1 versus 76.7±0.4 g/m(2); P CONCLUSIONS: Active smoking and cumulative cigarette exposure were associated with subtle alterations in LV structure and function in an elderly, community-based population free of overt coronary artery disease and heart failure. |
DOI | 10.1161/CIRCIMAGING.116.004950 |
Alternate Journal | Circ Cardiovasc Imaging |
PubMed ID | 27625349 |
PubMed Central ID | PMC5193104 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States K08 HL116792 / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R00 HL107642 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |