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Kidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study.

TitleKidney function and sudden cardiac death in the community: The Atherosclerosis Risk in Communities (ARIC) Study.
Publication TypeJournal Article
Year of Publication2016
AuthorsSuzuki T, Agarwal SK, Deo R, Sotoodehnia N, Grams ME, Selvin E, Calkins H, Rosamond WD, Tomaselli G, Coresh JJ
Secondary AuthorsMatsushita K
JournalAm Heart J
Volume180
Pagination46-53
Date Published2016 10
ISSN1097-6744
KeywordsBiomarkers, Creatinine, Death, Sudden, Cardiac, Female, Glomerular Filtration Rate, Humans, Kidney, Kidney Function Tests, Male, Middle Aged, Proportional Hazards Models, Renal Insufficiency, Chronic, Risk Factors
Abstract

BACKGROUND: Individuals with chronic kidney disease, particularly those requiring dialysis, are at high risk of sudden cardiac death (SCD). However, comprehensive data for the full spectrum of kidney function and SCD risk in the community are sparse. Furthermore, newly developed equations for estimated glomerular filtration rate (eGFR) and novel filtration markers might add further insight to the role of kidney function in SCD.

METHODS: We investigated the associations of baseline eGFRs using serum creatinine, cystatin C, or both (eGFRcr, eGFRcys, and eGFRcr-cys); cystatin C itself; and ╬▓2-microglobulin (B2M) with SCD (205 cases through 2001) among 13,070 black and white ARIC participants at baseline during 1990-1992 using Cox regression models accounting for potential confounders.

RESULTS: Low eGFR was independently associated with SCD risk: for example, hazard ratio for eGFR

CONCLUSIONS: Kidney function was independently and robustly associated with SCD in the community, particularly when cystatin C or B2M was used. These results suggest the potential value of kidney function as a risk factor for SCD and the advantage of novel filtration markers over eGFRcr in this context.

DOI10.1016/j.ahj.2016.07.004
Alternate JournalAm Heart J
PubMed ID27659882
PubMed Central IDPMC5074685
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States
R01 HL111089 / HL / NHLBI NIH HHS / United States
R01 HL116747 / HL / NHLBI NIH HHS / United States