|Title||Biomarkers and degree of atherosclerosis are independently associated with incident atherosclerotic cardiovascular disease in a primary prevention cohort: The ARIC study.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Agarwala A, Virani S, Couper DJ, Chambless L, Boerwinkle E, Astor BC, Hoogeveen RC, Coresh JJ, Sharrett ARichey, Folsom AR, Mosley T, Ballantyne CM|
|Secondary Authors||Nambi V|
|Date Published||2016 10|
|Keywords||1-Alkyl-2-acetylglycerophosphocholine Esterase, Albuminuria, Atherosclerosis, Biomarkers, C-Reactive Protein, Cardiovascular Diseases, Carotid Intima-Media Thickness, Cohort Studies, Cystatin C, Female, Humans, Incidence, Lipoprotein(a), Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Primary Prevention, Prospective Studies, Smoking, Troponin T, United States|
BACKGROUND AND AIMS: Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort.
METHODS: 8127 participants from the ARIC study (4th visit, 1996-1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis.
RESULTS: While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis.
CONCLUSIONS: These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD.
|PubMed Central ID||PMC5081270|
|Grant List||HHSN268201100012C / HL / NHLBI NIH HHS / United States |
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States