Title | Lung function, respiratory symptoms and venous thromboembolism risk: the Atherosclerosis Risk in Communities Study. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Kubota Y, London SJ, Cushman M, Chamberlain AM, Rosamond WD, Heckbert SR, Zakai N |
Secondary Authors | Folsom AR |
Journal | J Thromb Haemost |
Volume | 14 |
Issue | 12 |
Pagination | 2394-2401 |
Date Published | 2016 12 |
ISSN | 1538-7836 |
Keywords | Anticoagulants, Atherosclerosis, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Incidence, Lung Diseases, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Respiration, Respiratory Function Tests, Risk Factors, Spirometry, Venous Thromboembolism |
Abstract | Essentials The association of lung function with venous thromboembolism (VTE) is unclear. Chronic obstructive pulmonary disease (COPD) patterns were associated with a higher risk of VTE. Symptoms were also associated with a higher risk of VTE, but a restrictive pattern was not. COPD may increase the risk of VTE and respiratory symptoms may be a novel risk marker for VTE. SUMMARY: Background The evidence for the association between chronic obstructive pulmonary disease (COPD) and venous thromboembolism (VTE) is limited. There is no study investigating the association between restrictive lung disease (RLD) and respiratory symptoms with VTE. Objectives To investigate prospectively the association of lung function and respiratory symptoms with VTE. Patients/Methods In 1987-1989, we assessed lung function by using spirometry, and obtained information on respiratory symptoms (cough, phlegm, and dyspnea) in 14 654 participants aged 45-64 years, without a history of VTE or anticoagulant use, and followed them through 2011. Participants were classified into four mutually exclusive groups: 'COPD' (forced expiratory volume in 1 s [FEV ]/forced vital capacity [FVC] below the lower limit of normal [LLN]), 'RLD' (FEV /FVC ≥ LLN and FVC |
DOI | 10.1111/jth.13525 |
Alternate Journal | J Thromb Haemost |
PubMed ID | 27696765 |
PubMed Central ID | PMC5378065 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States Z01 ES043012-09 / / Intramural NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States R01 HL059367 / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |