|Title||The Importance of Mid-to-Late-Life Body Mass Index Trajectories on Late-Life Gait Speed.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||B Windham G, Griswold ME, Wang W, Kucharska-Newton AMaria, Demerath EW, Gabriel KPettee, Pompeii LA, Butler K, Wagenknecht L, Kritchevsky S|
|Secondary Authors||Mosley TH|
|Journal||J Gerontol A Biol Sci Med Sci|
|Date Published||2017 Aug 01|
|Keywords||African Continental Ancestry Group, Aged, Aging, Body Mass Index, European Continental Ancestry Group, Female, Gait, Humans, Longitudinal Studies, Male, Middle Aged, Overweight, Risk Factors, Statistics as Topic, United States, Walking, Walking Speed|
Background: Prior studies suggest being overweight may be protective against poor functional outcomes in older adults.
Methods: Body mass index (BMI, kg/m2) was measured over 25 years across five visits (1987-2011) among Atherosclerosis Risk in Communities Study participants (baseline Visit 1 n = 15,720, aged 45-64 years). Gait speed was measured at Visit 5 ("late-life", aged ≥65 years, n = 6,229). BMI trajectories were examined using clinical cutpoints and continuous mixed models to estimate effects of patterns of BMI change on gait speed, adjusting for demographics and comorbidities.
Results: Mid-life BMI (baseline visit; 55% women; 27% black) was associated with late-life gait speed 25 years later; gait speeds were 94.3, 89.6, and 82.1 cm/s for participants with baseline normal BMI (
Conclusion: Being overweight in older age was not protective of mobility function. Maintaining a normal BMI in mid- and late-life may help preserve late-life mobility.
|Alternate Journal||J Gerontol A Biol Sci Med Sci|
|PubMed Central ID||PMC5861851|
|Grant List||U01 HL096812 / HL / NHLBI NIH HHS / United States |
U01 HL096917 / HL / NHLBI NIH HHS / United States
U01 HL096902 / HL / NHLBI NIH HHS / United States
U01 HL096814 / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
U01 HL096899 / HL / NHLBI NIH HHS / United States