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and Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.

Title and Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
Publication TypeJournal Article
Year of Publication2017
AuthorsLi M, Li Y, Weeks O, et al.
Secondary AuthorsChu AY
Corporate AuthorsCHARGE Glycemic-T2D Working Group,, CHARGE Blood Pressure Working Group,
JournalJ Am Soc Nephrol
Volume28
Issue3
Pagination981-994
Date Published2017 Mar
ISSN1533-3450
KeywordsAnimals, Exome, Genetic Loci, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney, Protein Tyrosine Phosphatases, Proto-Oncogene Proteins, Son of Sevenless Proteins, Zebrafish
Abstract

Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine (eGFRcrea) among participants of European ancestry from the CKDGen Consortium (: 111,666; : 48,343). In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (, , and ;

DOI10.1681/ASN.2016020131
Alternate JournalJ Am Soc Nephrol
PubMed ID27920155
PubMed Central IDPMC5328154
Grant ListP30 ES010126 / ES / NIEHS NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
R21 DK112087 / DK / NIDDK NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
S10 OD018522 / OD / NIH HHS / United States
R25 GM062459 / GM / NIGMS NIH HHS / United States
S10 OD020069 / OD / NIH HHS / United States
R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 HL112064 / HL / NHLBI NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
R01 HL087660 / HL / NHLBI NIH HHS / United States
R01 HL119443 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
CZD/16/6/4 / CSO_ / Chief Scientist Office / United Kingdom
MC_PC_U127561128 / MRC_ / Medical Research Council / United Kingdom
UM1 CA182913 / CA / NCI NIH HHS / United States
R21 HL123677 / HL / NHLBI NIH HHS / United States
R01 DK107904 / DK / NIDDK NIH HHS / United States