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Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study.

TitleAssociation between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study.
Publication TypeJournal Article
Year of Publication2017
AuthorsPokharel Y, Sun W, Villareal DT, Selvin E, Virani SS, Ndumele CE, Hoogeveen RC, Coresh JJ, Boerwinkle E, Butler KR, Solomon SD, Pankow JS, Bozkurt B, Ballantyne CM
Secondary AuthorsNambi V
JournalEur J Prev Cardiol
Volume24
Issue6
Pagination628-638
Date Published2017 04
ISSN2047-4881
KeywordsBiomarkers, Coronary Disease, Female, Health Status, Heart Failure, Humans, Male, Metabolic Syndrome, Middle Aged, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, Troponin T, United States
Abstract

Background Metabolic syndrome (MetS) is associated with increased risk for cardiovascular disease, but there is heterogeneity in this risk. We evaluated whether high-sensitivity troponin T (hs-cTnT), a marker associated with cardiovascular disease, can stratify risk in MetS. Methods We evaluated associations between MetS (and groups with similar number of MetS components) and incident heart failure hospitalization, coronary heart disease, stroke and death using hs-cTnT categories after adjusting for risk factors/markers between 1996 and 2011 in 8204 individuals in the Atherosclerosis Risk In Communities study. Results The mean age of the population was 63 years (56% women, 19% Blacks). hs-cTnT levels were higher with MetS and with increasing MetS components. In individuals with MetS, higher hs-cTnT levels were associated with increased hazard ratios for heart failure, coronary heart disease and death. Within each number of MetS components, higher hs-cTnT was associated with progressively higher heart failure, coronary heart disease and death hazards. The association was particularly strong for heart failure. With increasing hs-cTnT categories, the hazard ratios (95% confidence interval) for heart failure in individuals with MetS increased gradually from 1.68 (1.31-2.16) to 3.76 (2.69-5.26) ( p-trend 

DOI10.1177/2047487316683071
Alternate JournalEur J Prev Cardiol
PubMed ID27941157
PubMed Central IDPMC5405860
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
R01 DK089174 / DK / NIDDK NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
K24 DK106414 / DK / NIDDK NIH HHS / United States
T32 HL110837 / HL / NHLBI NIH HHS / United States
I01 CX000906 / CX / CSRD VA / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
R01 AG031176 / AG / NIA NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States