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Race-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study.

TitleRace-Related Differences in Left Ventricular Structural and Functional Remodeling in Response to Increased Afterload: The ARIC Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsFernandes-Silva MM, Shah AM, Hegde S, Gonçalves A, Claggett B, Cheng S, Nadruz W, Kitzman DW, Konety S, Matsushita K, Mosley T, Lam CSP, Borlaug BA
Secondary AuthorsSolomon SD
JournalJACC Heart Fail
Date Published2017 03
KeywordsAfrican Americans, Aged, Aged, 80 and over, Diabetes Mellitus, Echocardiography, Ethnic Groups, European Continental Ancestry Group, Female, Heart Failure, Humans, Hypertension, Independent Living, Male, Obesity, Prevalence, Vascular Stiffness, Ventricular Function, Left, Ventricular Remodeling

OBJECTIVES: The aim of this study was to evaluate racial differences in arterial elastance (Ea), which reflects the arterial afterload faced by the left ventricle, and its associations with cardiac structure and function. The hypothesis under study was that the left ventricle in blacks displays heightened afterload sensitivity compared with whites.

BACKGROUND: Chronic increasing in arterial afterload may be an important trigger for left ventricular (LV) remodeling and dysfunction that lead to heart failure. Racial differences in the predisposition to heart failure are well described, but the underlying mechanisms remain unclear.

METHODS: In total, 5,727 community-based, older ARIC (Atherosclerosis Risk In Community) study participants (22% black) who underwent echocardiography between 2011 and 2013 were studied.

RESULTS: Blacks were younger (mean age 75 ± 5 years vs. 76 ± 5 years), were more frequently female (66% vs. 57%), and had higher prevalence rates of obesity (46% vs. 31%), hypertension (94% vs. 80%), and diabetes mellitus (47% vs. 34%) than whites. Adjusting for these baseline differences, Ea was higher among blacks (1.96 ± 0.01 mm Hg/ml vs. 1.80 ± 0.01 mm Hg/ml). In blacks, Ea was associated with greater LV remodeling (LV mass index, β = 3.21 ± 0.55 g/m, p 

CONCLUSIONS: These community-based data suggest that black Americans display heightened afterload sensitivity as a stimulus for LV structural and functional remodeling, which may contribute to their greater risk for heart failure compared with white Americans.

Alternate JournalJACC Heart Fail
PubMed ID28017356
PubMed Central IDPMC5336438
Grant ListHHSN268201100011C / HL / NHLBI NIH HHS / United States
R00 HL107642 / HL / NHLBI NIH HHS / United States