Title | Age- and Sex-Related Influences on Left Ventricular Mechanics in Elderly Individuals Free of Prevalent Heart Failure: The ARIC Study (Atherosclerosis Risk in Communities). |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Hung C-L, Gonçalves A, Shah AM, Cheng S, Kitzman D |
Secondary Authors | Solomon SD |
Journal | Circ Cardiovasc Imaging |
Volume | 10 |
Issue | 1 |
Date Published | 2017 Jan |
ISSN | 1942-0080 |
Keywords | Age Factors, Aged, Aged, 80 and over, Atherosclerosis, Biomechanical Phenomena, Cross-Sectional Studies, Diastole, Echocardiography, Three-Dimensional, Female, Heart Failure, Hemodynamics, Humans, Hypertension, Male, Prevalence, Prospective Studies, Risk Factors, Sex Factors, Time Factors, Torsion, Mechanical, United States, Ventricular Dysfunction, Left, Ventricular Function, Left, Ventricular Remodeling |
Abstract | BACKGROUND: Advanced age is related to left ventricular (LV) remodeling. We sought to investigate the relationships between aging, elevated hemodynamic load, cardiac mechanics, and LV remodeling in an elderly community-based population. METHODS AND RESULTS: We studied 1105 subjects (76±5 years, 61% women) without prevalent heart failure, who attended the visit 5 of the ARIC study (Atherosclerosis Risk in Communities). LV global longitudinal strain, global circumferential strain, and torsion indices were analyzed using 3-dimensional echocardiography. Advanced age was associated with greater LV concentricity, lower myocardial diastolic relaxation, reduced global longitudinal strain (adjusted estimate, 0.39±0.19% (SE)/decade; P=0.038), borderline greater global circumferential strain (adjusted estimate, -0.59±0.36% (SE)/decade; P=0.08), and higher torsion indices (adjusted estimate for torsion, 0.33±0.04° (SE)/decade; P CONCLUSIONS: In an asymptomatic, senescent community-dwelling population, we observed a distinct, sex-specific pattern of cardiac remodeling. Although we observed worse diastolic and longitudinal function with advanced age or elevated load in both sexes, a significant increase of torsion was more pronounced in women. |
DOI | 10.1161/CIRCIMAGING.116.004510 |
Alternate Journal | Circ Cardiovasc Imaging |
PubMed ID | 28093411 |
PubMed Central ID | PMC5260486 |
Grant List | HHSN268201100012C / HL / NHLBI NIH HHS / United States K08 HL116792 / HL / NHLBI NIH HHS / United States HHSN268201100009I / HL / NHLBI NIH HHS / United States HHSN268201100010C / HL / NHLBI NIH HHS / United States HHSN268201100008C / HL / NHLBI NIH HHS / United States HHSN268201100005G / HL / NHLBI NIH HHS / United States HHSN268201100008I / HL / NHLBI NIH HHS / United States HHSN268201100007C / HL / NHLBI NIH HHS / United States HHSN268201100011I / HL / NHLBI NIH HHS / United States HHSN268201100011C / HL / NHLBI NIH HHS / United States R00 HL107642 / HL / NHLBI NIH HHS / United States HHSN268201100006C / HL / NHLBI NIH HHS / United States HHSN268201100005I / HL / NHLBI NIH HHS / United States HHSN268201100009C / HL / NHLBI NIH HHS / United States HHSN268201100005C / HL / NHLBI NIH HHS / United States HHSN268201100007I / HL / NHLBI NIH HHS / United States |