|Title||Relationship Between Midlife Cardiovascular Health and Late-Life Physical Performance: The ARIC Study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||B Windham G, Harrison KL, Lirette ST, Lutsey PL, Pompeii LA, Gabriel KPettee, Koton S, Steffen LM, Griswold ME|
|Secondary Authors||Mosley TH|
|Journal||J Am Geriatr Soc|
|Date Published||2017 May|
|Keywords||African Continental Ancestry Group, Age Factors, Cardiovascular Diseases, European Continental Ancestry Group, Exercise, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors|
OBJECTIVES: To examine the association between midlife cardiovascular health and physical performance 25 years later.
DESIGN: Cohort study (Atherosclerosis Risk in Communities Study); multinomial logistic and logistic regression adjusted for demographic characteristics and clinical measures.
SETTING: Four U.S. communities: Forsyth County, North Carolina; Washington County, Maryland; Minneapolis, Minnesota; and Jackson, Mississippi.
PARTICIPANTS: Individuals aged 54.2 ± 5.8 at baseline (N = 15,744; 55% female, 27% black).
MEASUREMENTS: Cardiovascular health was measured at baseline using the American Heart Association's Life's Simple 7 (LS7) score (0-14) and LS7 component categories (poor, intermediate, ideal) for each risk factor. The Short Physical Performance Battery (SPPB) was used to quantify physical function as ordinal (0-12) and categorical (low (0-6), fair (7-9), good (10-12) outcomes.
RESULTS: Mean baseline LS7 score was 7.9 ± 2.4; 6,144 (39%) individuals returned 25 years later for the fifth ARIC examination, at which point the SPPB was administered. Of 5,916 individuals who completed the SPPB, 3,288 (50%) had good physical performance. Each 1-unit increase in LS7 score was associated with a 17% higher SPPB score (rate ratio (RR) = 1.17, 95% confidence interval (CI) = 1.15-1.19) and a 29% greater chance of having a late-life SPPB score of 10 or greater compared to SPPB score of less than 10 (RR = 1.29, 95% CI = 1.25-1.34). Ideal baseline glucose (RR = 2.53, 95% CI = 2.24-2.87), smoking (RR = 1.97, 95% CI = 1.81-2.15), blood pressure (RR = 1.70, 95% CI = 1.54-1.88), body mass index (RR = 1.51, 95% CI = 1.37-1.66), and physical activity (RR = 1.31, 95% CI = 1.20-1.43) had the strongest associations with late-life SPPB score, adjusting for other LS7 components.
CONCLUSION: Better cardiovascular health during midlife may lead better physical functioning in older age.
|Alternate Journal||J Am Geriatr Soc|
|PubMed Central ID||PMC5435564|
|Grant List||T35 AG038027 / AG / NIA NIH HHS / United States |
HHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
R01 HL070825 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States