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BNP and obesity in acute decompensated heart failure with preserved vs. reduced ejection fraction: The Atherosclerosis Risk in Communities Surveillance Study.

TitleBNP and obesity in acute decompensated heart failure with preserved vs. reduced ejection fraction: The Atherosclerosis Risk in Communities Surveillance Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsKhalid U, Wruck LMiller, Quibrera PMiguel, Bozkurt B, Nambi V, Virani SS, Jneid H, Agarwal S, Chang PP, Loehr LR, Basra SSingh, Rosamond WD, Ballantyne CM
Secondary AuthorsDeswal A
JournalInt J Cardiol
Volume233
Pagination61-66
Date Published2017 Apr 15
ISSN1874-1754
KeywordsAcute Disease, Aged, Atherosclerosis, Biomarkers, Body Mass Index, Female, Heart Failure, Humans, Incidence, Male, Middle Aged, Natriuretic Peptide, Brain, Obesity, Morbid, Prognosis, Risk Assessment, Risk Factors, Stroke Volume, Survival Rate, United States, Ventricular Function, Left
Abstract

BACKGROUND: Levels of B-type natriuretic peptide (BNP), a prognostic marker in patients with heart failure (HF), are lower among HF patients with obesity or preserved Left Ventricular Ejection Fraction (LVEF). We examined the distribution and prognostic value of BNP across BMI categories in acute decompensated heart failure (ADHF) patients with preserved vs. reduced LVEF.

METHODS: We analyzed data from the Atherosclerosis Risk in Communities (ARIC) HF surveillance study which sampled and adjudicated ADHF hospitalizations in patients aged ≥55years from 4 US communities (2005-2009). We examined 5 BMI categories: underweight (

RESULTS: The cohort included 9820 weighted ADHF hospitalizations (58% HFrEF; 42% HFpEF). BNP levels were lower in HFpEF compared to HFrEF (p

CONCLUSIONS: BNP levels correlated inversely with BMI, and were higher in HFrEF compared to HFpEF. Obese patients with HFpEF and ADHF had a significant proportion with BNP levels below clinically accepted thresholds. Nevertheless, BNP was a predictor of mortality in ADHF across groups of BMI in HFpEF and HFrEF.

DOI10.1016/j.ijcard.2017.01.130
Alternate JournalInt J Cardiol
PubMed ID28185703
PubMed Central IDPMC5368080
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States