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Physical Activity, Vitamin D, and Incident Atherosclerotic Cardiovascular Disease in Whites and Blacks: The ARIC Study.

TitlePhysical Activity, Vitamin D, and Incident Atherosclerotic Cardiovascular Disease in Whites and Blacks: The ARIC Study.
Publication TypeJournal Article
Year of Publication2017
AuthorsChin K, Zhao D, Tibuakuu M, Martin SS, Ndumele CE, Florido R, B Windham G, Guallar E, Lutsey PL
Secondary AuthorsMichos ED
JournalJ Clin Endocrinol Metab
Volume102
Issue4
Pagination1227-1236
Date Published2017 04 01
ISSN1945-7197
KeywordsAfrican Continental Ancestry Group, Atherosclerosis, Cross-Sectional Studies, European Continental Ancestry Group, Exercise, Female, Humans, Incidence, Male, Middle Aged, Prospective Studies, Vitamin D, Vitamin D Deficiency
Abstract

Context: Physical activity (PA) is associated with 25-hydroxyvitamin D [25(OH)D] levels. Both are associated with atherosclerotic cardiovascular disease (ASCVD), but their joint association with ASCVD risk is unknown.

Objective: To examine the relationship between PA and 25(OH)D, and assess effect modification of 25(OH)D and PA with ASCVD.

Design: Cross-sectional and prospective study.

Setting: Community-dwelling cohort.

Participants: A total of 10,342 participants free of ASCVD, with moderate- to vigorous-intensity PA assessed (1987 to 1989) and categorized per American Heart Association (AHA) guidelines (recommended, intermediate, or poor).

Main Outcome Measures: Serum 25(OH)D levels (1990 to 1992) and ASCVD events (i.e., incident myocardial infarction, fatal coronary disease, or stroke) through 2013.

Results: Participants had mean age of 54 years, and were 57% women, 21% black, 30% 25(OH)D deficient [

Conclusion: PA is linearly associated with higher 25(OH)D levels in whites. PA and 25(OH)D may have synergistic beneficial effects on ASCVD risk.

DOI10.1210/jc.2016-3743
Alternate JournalJ Clin Endocrinol Metab
PubMed ID28323928
PubMed Central IDPMC5460730
Grant ListHHSN268201100012C / HL / NHLBI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
R01 HL103706 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
HHSN268201100008C / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
HHSN268201100008I / HL / NHLBI NIH HHS / United States
HHSN268201100007C / HL / NHLBI NIH HHS / United States
R01 NS072243 / NS / NINDS NIH HHS / United States
HHSN268201100011I / HL / NHLBI NIH HHS / United States
HHSN268201100011C / HL / NHLBI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
HHSN268201100007I / HL / NHLBI NIH HHS / United States