Title | and Loci Associate with Plasma Osmolality. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Böger CA, Gorski M, McMahon GM, et al. |
Secondary Authors | Cohen DM |
Journal | J Am Soc Nephrol |
Volume | 28 |
Issue | 8 |
Pagination | 2311-2321 |
Date Published | 2017 Aug |
ISSN | 1533-3450 |
Keywords | Aged, Continental Population Groups, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Middle Aged, Osmolar Concentration, Plasma, Sodium, Sodium-Bicarbonate Symporters, Transcription Factors, Water-Electrolyte Imbalance |
Abstract | Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study meta-analysis on plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent). In stage 1, we identified eight loci associated with plasma sodium concentration at |
DOI | 10.1681/ASN.2016080892 |
Alternate Journal | J Am Soc Nephrol |
PubMed ID | 28360221 |
PubMed Central ID | PMC5533231 |
Grant List | P60 AA010760 / AA / NIAAA NIH HHS / United States R01 HL087660 / HL / NHLBI NIH HHS / United States R01 HL088120 / HL / NHLBI NIH HHS / United States R01 HL119443 / HL / NHLBI NIH HHS / United States |