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and Loci Associate with Plasma Osmolality.

Title and Loci Associate with Plasma Osmolality.
Publication TypeJournal Article
Year of Publication2017
AuthorsBöger CA, Gorski M, McMahon GM, et al.
Secondary AuthorsCohen DM
JournalJ Am Soc Nephrol
Volume28
Issue8
Pagination2311-2321
Date Published2017 Aug
ISSN1533-3450
KeywordsAged, Continental Population Groups, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Middle Aged, Osmolar Concentration, Plasma, Sodium, Sodium-Bicarbonate Symporters, Transcription Factors, Water-Electrolyte Imbalance
Abstract

Disorders of water balance, an excess or deficit of total body water relative to body electrolyte content, are common and ascertained by plasma hypo- or hypernatremia, respectively. We performed a two-stage genome-wide association study meta-analysis on plasma sodium concentration in 45,889 individuals of European descent (stage 1 discovery) and 17,637 additional individuals of European descent (stage 2 replication), and a transethnic meta-analysis of replicated single-nucleotide polymorphisms in 79,506 individuals (63,526 individuals of European descent, 8765 individuals of Asian Indian descent, and 7215 individuals of African descent). In stage 1, we identified eight loci associated with plasma sodium concentration at

DOI10.1681/ASN.2016080892
Alternate JournalJ Am Soc Nephrol
PubMed ID28360221
PubMed Central IDPMC5533231
Grant ListP60 AA010760 / AA / NIAAA NIH HHS / United States
R01 HL087660 / HL / NHLBI NIH HHS / United States
R01 HL088120 / HL / NHLBI NIH HHS / United States
R01 HL119443 / HL / NHLBI NIH HHS / United States