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Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.

TitleDiscovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.
Publication TypeJournal Article
Year of Publication2017
AuthorsC Y Ng M, Graff M, Lu Y, et al.
Secondary AuthorsNorth KE
Corporate AuthorsBone Mineral Density in Childhood Study(BMDCS) Group
JournalPLoS Genet
Volume13
Issue4
Paginatione1006719
Date Published2017 Apr
ISSN1553-7404
KeywordsAdiposity, African Continental Ancestry Group, Anthropometry, Body Mass Index, Chromosome Mapping, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Male, Obesity, Polymorphism, Single Nucleotide, Serine Endopeptidases, Transcription Factor 7-Like 2 Protein, Waist-Hip Ratio
Abstract

Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African ancestry genomes. We performed large scale meta-analyses and replications in up to 52,895 individuals for BMI and up to 23,095 individuals for WHRadjBMI from the African Ancestry Anthropometry Genetics Consortium (AAAGC) using 1000 Genomes phase 1 imputed GWAS to improve coverage of both common and low frequency variants in the low linkage disequilibrium African ancestry genomes. In the sex-combined analyses, we identified one novel locus (TCF7L2/HABP2) for WHRadjBMI and eight previously established loci at P

DOI10.1371/journal.pgen.1006719
Alternate JournalPLoS Genet
PubMed ID28430825
PubMed Central IDPMC5419579
Grant ListU01 HG007417 / HG / NHGRI NIH HHS / United States
K99 HL130580 / HL / NHLBI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
U10 CA037429 / CA / NCI NIH HHS / United States
U01 AG009740 / AG / NIA NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
S10 OD018522 / OD / NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
R01 HD056465 / HD / NICHD NIH HHS / United States
P30 DK020541 / DK / NIDDK NIH HHS / United States
R01 CA088164 / CA / NCI NIH HHS / United States
R01 DK089256 / DK / NIDDK NIH HHS / United States
R01 HL117078 / HL / NHLBI NIH HHS / United States
R01 HL055673 / HL / NHLBI NIH HHS / United States
K01 HL135405 / HL / NHLBI NIH HHS / United States
U54 CA163069 / CA / NCI NIH HHS / United States
P30 ES010126 / ES / NIEHS NIH HHS / United States
R01 DK113003 / DK / NIDDK NIH HHS / United States
U54 MD007586 / MD / NIMHD NIH HHS / United States
U01 HL130114 / HL / NHLBI NIH HHS / United States
U01 CA127298 / CA / NCI NIH HHS / United States
UG1 CA189974 / CA / NCI NIH HHS / United States
UM1 CA182883 / CA / NCI NIH HHS / United States
R01 HL118267 / HL / NHLBI NIH HHS / United States